Protein Info for Pf6N2E2_2445 in Pseudomonas fluorescens FW300-N2E2

Annotation: Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00357: methionine-R-sulfoxide reductase
  • amino acids 6 to 129 (124 residues), 192 bits, E=2.1e-61
• PF01641: SelR
  • amino acids 10 to 128 (119 residues), 188 bits, E=2.5e-60

Best Hits

Swiss-Prot: 93% identical to MSRB_PSEF5: Peptide methionine sulfoxide reductase MsrB (msrB) from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

KEGG orthology group: K07305, peptide-methionine (R)-S-oxide reductase [EC: 1.8.4.12] (inferred from 100% identity to pba:PSEBR_a1630)

MetaCyc: 57% identical to methionine sulfoxide reductase B (Escherichia coli K-12 substr. MG1655)
L-methionine (R)-S-oxide reductase. [EC: 1.8.4.14]; Peptide-methionine (R)-S-oxide reductase. [EC: 1.8.4.14, 1.8.4.12]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.12)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.12 or 1.8.4.14

Sequence Analysis Tools

See A0A165Z8R4 at UniProt or InterPro

Protein Sequence (130 amino acids)

>Pf6N2E2_2445 Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12) (Pseudomonas fluorescens FW300-N2E2)
MEKLEKTLEEWRSMLDPEQYNVCRLKGTERPFSGKYNATKTDGVYHCICCNEPLFDSQTK
FDSGCGWPSFYAPIEGSAVVEVRDVSHGMIRTEVVCAKCDAHLGHVFPDGPPPTGLRYCI
NSVCLDLVPR