Protein Info for Pf6N2E2_222 in Pseudomonas fluorescens FW300-N2E2

Annotation: RND efflux system, inner membrane transporter CmeB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1048 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 342 to 361 (20 residues), see Phobius details amino acids 368 to 390 (23 residues), see Phobius details amino acids 396 to 415 (20 residues), see Phobius details amino acids 441 to 462 (22 residues), see Phobius details amino acids 473 to 496 (24 residues), see Phobius details amino acids 541 to 560 (20 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 947 (25 residues), see Phobius details amino acids 971 to 990 (20 residues), see Phobius details amino acids 1000 to 1024 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 1 to 1026 (1026 residues), 1289.4 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1037 (1037 residues), 1592.9 bits, see alignment E=0 PF03176: MMPL" amino acids 343 to 498 (156 residues), 31.9 bits, see alignment E=1e-11

Best Hits

Swiss-Prot: 60% identical to MEXB_PSEAE: Multidrug resistance protein MexB (mexB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 68% identity to aav:Aave_2111)

MetaCyc: 60% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165YNE7 at UniProt or InterPro

Protein Sequence (1048 amino acids)

>Pf6N2E2_222 RND efflux system, inner membrane transporter CmeB (Pseudomonas fluorescens FW300-N2E2)
MARFFIDRPIFAWVIAIVIMLAGALSISQLPLEQYPDIAPPTVRISATYTGASAKTVEDS
VTQVIEQQMKGLDNLTYMSASSSSDGSASISLTFTAGTNPDVAQMQVQNKLQQAESRLPQ
SVQSEGLTVTKGGSDFLMIAALASDNPSVTGTQIGDYISSTLLDSISRIDGVGDVQTLGS
GYAMRIWLDPALLEKYALMPSDVSTALEAQNTEVSAGQLGAMPAVKGQQLNATISARSKL
QTVEEFRNVVVKSTSDGAVVLLGDVARVELGSESYDVSSALNGKPAAAMGVQLAAGANAL
NVGEAVKAKLKELEAFYPTELQLKNVIAYDTTPFVSLSIEEVVKSLGEAIVLVVLIMFLF
LQNLRATLIPAITVPVVLLGTFGVLALFGYSINTLTMFAMVLAIGLLVDDAIVVVENVER
VMGEQGLSALDATRQSMDEITSALVGIALVLSAVFIPMAFFGGSTGVIYRQFSVTIVSAM
VLSVLVAMTLTPALCATLLKPSDGQGHGAQRGFFGWFNRTFERAAEAYKRQVGGILQRGR
VGWLVYGLVLLLMAVGYFSLPTSFLPDEDQGILMAQVQLPVGATDSRTQAVVKQFESYLL
EQPEVEALISISGLGMNGNSQNSARAFIRLKDWSERTGAGQDAASFAQRATMALSSIGDA
NVFVMQPPAVRGLGQTSGFDLQLKDLAGLGHDTLVAAREKLIELANQDPRLLGVRSNGLD
DAPQLKVSIDDRKAGALSLSTSDINTTLSTALGGTYVNDFLNQGRVKKVYVQGEAAARMQ
AADLEHWFVRNSNDEMVPFSSFASSSWSYGSPLLERYNGNASLEVVGDPAPGVSSGDAMD
AVQALVKQLPEGIGYEWTGQSYQLRLSGSQAPLLYGISVLFVFLCLAALYESWSVPFSVM
LVVPLGVVGAVLATRVSGLSNDVYFQVGLLTTVGLAAKNAILIVEFAKHLQEQGNSLREA
TLIAVRQRLRPILMTSLAFMFGVLPLALSSGAGSAGRQAIGTGVLGGMLSATVLGIFFVP
LFFVQIRRRFGRVSTVSTSVPSAQSGDA