Protein Info for Pf6N2E2_1949 in Pseudomonas fluorescens FW300-N2E2

Annotation: RND efflux system, inner membrane transporter CmeB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1051 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 339 to 359 (21 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details amino acids 438 to 459 (22 residues), see Phobius details amino acids 471 to 497 (27 residues), see Phobius details amino acids 541 to 559 (19 residues), see Phobius details amino acids 875 to 893 (19 residues), see Phobius details amino acids 900 to 920 (21 residues), see Phobius details amino acids 926 to 949 (24 residues), see Phobius details amino acids 974 to 995 (22 residues), see Phobius details amino acids 1007 to 1032 (26 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1045 (1045 residues), 1763.1 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1029 (1029 residues), 1312.1 bits, see alignment E=0 PF03176: MMPL" amino acids 296 to 513 (218 residues), 36.6 bits, see alignment E=2.6e-13 amino acids 839 to 1039 (201 residues), 22.8 bits, see alignment E=4.1e-09

Best Hits

Swiss-Prot: 75% identical to MEPB_PSEPU: Multidrug/solvent efflux pump membrane transporter MepB (mepB) from Pseudomonas putida

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 63% identity to abo:ABO_0964)

MetaCyc: 64% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A159ZX99 at UniProt or InterPro

Protein Sequence (1051 amino acids)

>Pf6N2E2_1949 RND efflux system, inner membrane transporter CmeB (Pseudomonas fluorescens FW300-N2E2)
MSKYFIDRPIFAWVLALIIMLVGALSILNLPINQYPDIAPPAVAIQVSYPGASAQTVQDT
VVQVIEQQMNGIDNLRYISSESNADGSMRIIVTFNQGTNPDIAQVQVQNKLNLATPLLPR
EVQQQGLRVTKFQQNFMMFIGLVSTDGKHTKEDLSNYIVSNIQDPISRTSGVGDFQIWGT
QYAMRVWLDPAKLNQFQLTPVDVTEAIEAQNVQVASGTIGGLPARKGTVFTATIIGKTRL
QTSEQFGDILLKVNSDGSQVRLSDVADISLGGENYSINAQANGKPASGIAIRLATGANAL
DTARAIRATVDRLKPFFPAGIEAVYPYDTTPVVTESISGVMHTLGEAVVLVFLVMLLFLQ
NLRATIITTLTVPVVLLGTFGVLAAAGFSINTLTMFGMILAIGLLVDDAIVVVENVERVM
AEEHLSPREATRKSMGQIQGALVGIALVLSAVLLPMAFFGGSTGVIYRQFSITIVSAMAL
SVFVALVFTPALCATLLKPIDPTKHGQPKRGFFGWFNRRFDACVNGYEQGVGQIIRHRVP
GFMVYLVIVAGTIWMFARIPTSFLPDEDQGLIFTQVQTPANSSAETTQKVLDRMSQYLLD
KEHGEGKAVATVFTVNGFNFAGRGQNSGIAFVNLKPWDERDSDNTVFKIAQRAQQEFLKY
RDALVYAVVPPSVLELGNATGFDFYLQDQDSVGHQKLMEARGKFLELAAQSPVLAGVRPN
GLADEPQYHLTIDDERARAMGISLADINTTLSVAYGSSYVNDFVDRGRVKRVYVQGQPDS
RSTAEDLSKWFVRNNQGQMVPFSAFASAEWIFGSPKLSRYNGVPAEQILGTPAPGYSSGQ
AMAEVERIAEQLPPGVGISFTGLSYEERLSGSQAPALYALSILVVFLCLAALYESWSIPI
AVILVVPLGVIGALMATALRGLSNDVFFQVGLLVTVGLAAKNAILIVEFAKELNEKGQPL
LEATVEACRMRLRPIVMTSLAFILGVLPLTISSGAGSGSQHAIGTGVIGGMITATVLAIF
WVPLFFVSISTLFKGSRKKRDETAMREEAGQ