Protein Info for Pf1N1B4_4178 in Pseudomonas fluorescens FW300-N1B4

Annotation: Cell division protein FtsH (EC 3.4.24.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 595 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 105 to 123 (19 residues), see Phobius details PF06480: FtsH_ext" amino acids 11 to 95 (85 residues), 36.8 bits, see alignment E=9.9e-13 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 102 to 590 (489 residues), 677.2 bits, see alignment E=7.2e-208 PF00004: AAA" amino acids 193 to 324 (132 residues), 153.3 bits, see alignment E=1.2e-48 PF17862: AAA_lid_3" amino acids 352 to 390 (39 residues), 46.4 bits, see alignment 5.8e-16 PF01434: Peptidase_M41" amino acids 407 to 590 (184 residues), 196.9 bits, see alignment E=8e-62

Best Hits

Swiss-Prot: 75% identical to FTSH_PSEP1: ATP-dependent zinc metalloprotease FtsH (ftsH) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 84% identity to pba:PSEBR_a2532)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (595 amino acids)

>Pf1N1B4_4178 Cell division protein FtsH (EC 3.4.24.-) (Pseudomonas fluorescens FW300-N1B4)
MKKNDQWNLSYFAIAFIVLSLAQIFFGERQAVQPLPYSQFLQLLNEQKVSDLRVDKDQIS
GKLQEPIDGRERFSTVRVDPALATELSQSGVGFTGTTENTFMNSLLGWLLPFVLIMVFWN
FLFRGMADKQGLGGLMNVGKSRARVFVERDTGVTFADVAGIDEAKAELVEIVSFLKDKDK
YARLGAHIPKGTLLVGPPGTGKTLVAKAIAGEAGVPFFSISGSEFVEMFVGVGAARVRDL
FEQARQAAPCIIFIDELDALGKMRGVGTLGGNDEKEQTLNQLLAELDGFDPREGVVLLAA
TNRPEVLDPALLRAGRFDRQILIDRPDRKGREAILKVHMQKITVEPGLDGARIAEITTGF
TGADLANLVNEAAIVATRRGAEAVSLNDFTAAVERLIAGLERKSSLLDPDERRVVAYHEM
GHALAASTLPAMDPVHKVSIVPRAIGSLGYTLQRPTEDHFLISCQTLKDRIVVLMAGRAA
EDLVYGQISTGAADDLGRATDIARQLITRFGMSAELGQSVLERQNATYLGDRMATVGEKD
YSEQTAREIDLGIRALLDEAYQRAKALLESRRADLDEGARLLLEKETLTPRNSRR