Protein Info for Pf1N1B4_2179 in Pseudomonas fluorescens FW300-N1B4

Annotation: Adenylate cyclase (EC 4.6.1.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 948 PF12633: Adenyl_cycl_N" amino acids 20 to 217 (198 residues), 260.1 bits, see alignment E=1.6e-81 PF01295: Adenylate_cycl" amino acids 245 to 802 (558 residues), 402.6 bits, see alignment E=3.3e-124

Best Hits

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 91% identity to pfo:Pfl01_5493)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161Z7E4 at UniProt or InterPro

Protein Sequence (948 amino acids)

>Pf1N1B4_2179 Adenylate cyclase (EC 4.6.1.1) (Pseudomonas fluorescens FW300-N1B4)
MTRTHEIRPDLDEGIDRKVLSQLRARFLKLNEGRMARAMEGLSTRQQTVLTLLPLFFHVN
HPLLPGYVSGSTPAGLSNFEPDANTLAEAQRLTRSFSYKPRHGSNPPRPIHGLFLMGSLG
TLAQADQSDMDVWVCHGPDLSESELSELRKKCQLLEIWAASQGAEAHFFLIDPARFVLGE
RDTQLSSEDCGTTQHYLLLDEFYRTAIWLAGRTPIWWLVPVYEEAAYDRYTHTLLSKRFI
RADETLDLGHLAYIPPGEFIGAGLWQLFKGIESPYKSVLKLLLTEVYASEHPKVQCLSLR
FKQAVFANRLDLDELDPYVVVYRRIEEYLTARGEPERLELVRRALYLKVNRKLTGSSGRT
QSWQRSLLERLANEWQWDQRQLALLDSRSQWKVRQVSAERRTLVGELNYSYRFLTQFARN
EQTVSLINKRDLNVLGRRLYAAFERKADKVEFINPGIAPDLAEDTLTLVQAPNKKEPGQT
QWGLYNGSLAAHEWEHFAPIKRSRQLLELLTWCHRNGVIDSSTRLALHPGTSDLSEFELF
NLLGSLQQSIALPLTTVAEEPLLRASVPSEVLILVNVGIDPLKHHRDLNILMTTERTDSL
SYAGVRENLVLTLDQVTLNSWNEVLVSRFDGPHALLDCLRDYLNNLPDGPQQPKLRVRCF
CHNRAQFIARRVEEILDTAQNLLLSKLNHRYLIQVQQHYHVLELVPGQVNHIALATLPAL
FDYLGEELASYSPFHLDPMALEDHDLALILPMGQPDCVQVFYRINEHQADVYVLDEFNAL
WQQRLPYHDEQSLLVPLQRFLQSIQYRRDALLPMDTAQPLSLETLYYQLLPSGSARARRV
EARPAPQTPVNKPFYDVQAIVGKAAPGQVQVTLYCNQREFSELEHGDELFSVVAREIVEQ
RRETERYRCYITDLDLSGLLGDGQGSSHLYLRYKADLERALNEALEQV