Protein Info for Pf1N1B4_1532 in Pseudomonas fluorescens FW300-N1B4

Annotation: Uroporphyrinogen III decarboxylase (EC 4.1.1.37)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01208: URO-D
  • amino acids 5 to 348 (344 residues), 469.2 bits, E=3.9e-145
• TIGR01464: uroporphyrinogen decarboxylase
  • amino acids 9 to 348 (340 residues), 440.9 bits, E=1.4e-136

Best Hits

Swiss-Prot: 97% identical to DCUP_PSEFS: Uroporphyrinogen decarboxylase (hemE) from Pseudomonas fluorescens (strain SBW25)

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 97% identity to pfo:Pfl01_0415)

MetaCyc: 73% identical to uroporphyrinogen decarboxylase (Escherichia coli K-12 substr. MG1655)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• superpathway of heme b biosynthesis from glycine (6/8 steps found)
• heme b biosynthesis I (aerobic) (3/4 steps found)
• heme b biosynthesis II (oxygen-independent) (3/4 steps found)
• heme b biosynthesis V (aerobic) (3/4 steps found)
• superpathway of heme b biosynthesis from uroporphyrinogen-III (4/6 steps found)
• heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Sequence Analysis Tools

See A0A161Z168 at UniProt or InterPro

Protein Sequence (355 amino acids)

>Pf1N1B4_1532 Uroporphyrinogen III decarboxylase (EC 4.1.1.37) (Pseudomonas fluorescens FW300-N1B4)
MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRAKAGDFMSLCMNPAFACEVT
MQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFKKVISTLADIEALPIPDPHK
DLGYVMDAVSTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKTKAMLYDNPQAMH
LLLDKLAQSVTSYLNGQIMAGAQAVQIFDTWGGNLSAAAYQEFSLAYMRKIVSGLIREHE
GRKVPVILFTKNGGLWLESIADAGADALGLDWTCDIGEARQRVGNKVALQGNMDPTVLYA
KPEAIRAEVGRILASYGKGSGHVFNLGHGITPEVDPEHAGAFLRAVHELSAQYHE