Protein Info for PFLU_RS23765 in Pseudomonas fluorescens SBW25-INTG

Annotation: AGE family epimerase/isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07221: GlcNAc_2-epim
  • amino acids 40 to 394 (355 residues), 414.1 bits, E=2.6e-128

Best Hits

KEGG orthology group: None (inferred from 100% identity to pfs:PFLU4847)

Predicted SEED Role

"N-acylglucosamine 2-epimerase (EC 5.1.3.8)" in subsystem Sialic Acid Metabolism (EC 5.1.3.8)

MetaCyc Pathways

• N-acetylneuraminate and N-acetylmannosamine degradation II (1/3 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.8

Sequence Analysis Tools

See C3JZ78 at UniProt or InterPro

Protein Sequence (419 amino acids)

>PFLU_RS23765 AGE family epimerase/isomerase (Pseudomonas fluorescens SBW25-INTG)
MTTQPLPVSSWLNAAAHHAWLAAEGQRLLAFAKASRLPDGFGNLNDRGQLPADARAETMN
TARMTHSFAMAHAMGLPGYAELVEHGVTCLNGPLRDAEHGGWFAAPHALDGNRGKAAYLH
AFVALAASSAVVAGAPGARTLLNDAIPIIDQFFWSEEEGVMLESFAQDWSGVEAYRGANS
NMHATEAFLALADVTGDTRWLDRALRIVERVIHTHAAGNQFMVIEHFDVHWQPLLGYNED
NPADGFRPYGITPGHGFEWARLVLHLEAARLQAGLVTPEWLVTDAKGLFASACEYAWAVD
GAPGIVYTLDWNHRPVVRERLHWTHAEASAAAQALLKRTGELHYETWYRRFWEFCEAHFI
DRLHGSWHHELSPHNQPSSNIWGGKPDLYHAWQAVVLPALPLAPSMASAIGAGLYVTSW