Protein Info for MPMX20_04569 in Enterobacter sp. TBS_079

Annotation: HTH-type transcriptional regulator RafR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 331 PF00356: LacI" amino acids 3 to 47 (45 residues), 41.9 bits, see alignment 1e-14 PF00532: Peripla_BP_1" amino acids 60 to 318 (259 residues), 176.6 bits, see alignment E=1.2e-55 PF13377: Peripla_BP_3" amino acids 173 to 330 (158 residues), 65.5 bits, see alignment E=9.7e-22

Best Hits

Swiss-Prot: 66% identical to RAFR_ECOLX: HTH-type transcriptional regulator RafR (rafR) from Escherichia coli

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 97% identity to enc:ECL_05079)

Predicted SEED Role

"Putative ThuR, regulatory protein for trehalosemaltose transport"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (331 amino acids)

>MPMX20_04569 HTH-type transcriptional regulator RafR (Enterobacter sp. TBS_079)
MSLKAIAKELGLSVTTVSRALNGYDDVSRETRARVEAEAQRRGYRPNTFARRLKMGKIDA
VGLVFPVHPVPLNNSVFMDMVGEISHELARHEIDLLLIADDDLADKHSYMRMVQSRRVDA
LIVAHTLDHDPRLEQLQAAGFPFLALGRSQLPQPYAWFDFDNYAGTYNATRWLIEKGHRR
IALLGESNNQAFITQRRQGYLDALREAGLSSEWLRAMPPSRRVGYATTNELLSLPQPPTA
IITDCNTHGDGAAMALAQRGLLCGENAVSLVVYDGLPQDSIVDVDVAAVIQSTRQGVGKQ
IADMVRQLINGDDIAQLQVLWQPEFFPGQTA