Protein Info for MPMX20_04487 in Enterobacter sp. TBS_079

Annotation: UDP-N-acetylglucosamine 2-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00236: UDP-N-acetylglucosamine 2-epimerase
  • amino acids 1 to 357 (357 residues), 552.3 bits, E=2.7e-170
• PF02350: Epimerase_2
  • amino acids 7 to 355 (349 residues), 421.7 bits, E=1e-130

Best Hits

Swiss-Prot: 87% identical to WECB_SALTI: UDP-N-acetylglucosamine 2-epimerase (wecB) from Salmonella typhi

KEGG orthology group: K01791, UDP-N-acetylglucosamine 2-epimerase [EC: 5.1.3.14] (inferred from 95% identity to enc:ECL_04999)

MetaCyc: 85% identical to UDP-N-acetylglucosamine 2-epimerase (Escherichia coli K-12 substr. MG1655)
UDP-N-acetylglucosamine 2-epimerase. [EC: 5.1.3.14]

Predicted SEED Role

"UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 5.1.3.14)

MetaCyc Pathways

• UDP-N-acetyl-α-D-mannosamine biosynthesis (1/1 steps found)
• CMP-N-acetylneuraminate biosynthesis II (bacteria) (1/3 steps found)
• CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (1/5 steps found)
• superpathway of CMP-sialic acids biosynthesis (2/15 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.14

Protein Sequence (361 amino acids)

>MPMX20_04487 UDP-N-acetylglucosamine 2-epimerase (Enterobacter sp. TBS_079)
MAPLVHALASDPDIEAKVCVTAQHREMLDQVLTLFSIVPDYDLNIMKPGQGLTEITCRIL
QELKPILESFKPDVVLVHGDTTTTVATSLAAFYQRIPVGHVEAGLRTGNLYSPWPEEANR
TLTGHLAMYHFAPTENSRQNLLRENIADNKIFVTGNTVIDALIWVRDRVLSNNDLQKELA
ARYPFLNNGKKTILVTGHRRESFGRGFEQICHALAEIAAQNQDVQIVYPVHLNPNVSEPV
NRILGHIENVLLIEPQDYLPFVWLMNHAWLILTDSGGIQEEAPSLGKPVLVMRETTERPE
AVKAGTVRLVGTNAQLIVEEVTRLLHDDEEYQAMSRAHNPYGDGQACGRILHALKHNRVS
L