Protein Info for MPMX20_04473 in Enterobacter sp. TBS_079

Annotation: Protein HemY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 399 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 41 to 62 (22 residues), see Phobius details TIGR00540: heme biosynthesis-associated TPR protein" amino acids 4 to 386 (383 residues), 393 bits, see alignment E=6e-122 PF07219: HemY_N" amino acids 26 to 132 (107 residues), 122.8 bits, see alignment E=1.3e-39 PF07719: TPR_2" amino acids 329 to 360 (32 residues), 24.9 bits, see alignment (E = 3.1e-09)

Best Hits

Swiss-Prot: 88% identical to HEMY_ECO57: Protein HemY (hemY) from Escherichia coli O157:H7

KEGG orthology group: K02498, HemY protein (inferred from 96% identity to enc:ECL_04990)

Predicted SEED Role

"Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (399 amino acids)

>MPMX20_04473 Protein HemY (Enterobacter sp. TBS_079)
MLKVLLLFILLIAGIVLGPMLAGHQGYVLIQTDNYNIETSVTGLVIILILGVVVLLAVEW
ILRRIFRTGAHTRGWFVGRKRRRARKQTEQALLKLAEGDYQQVEKLMSKNADHAEQPVVN
YLLAAEAAQQRGDEARANQHLERASELSPKDPIPVEITRVRLQLARNENHAARHGIDRLL
EVAPRHPEVLRLAEQAYIRTGAWGSLLDIIPSMAKADVGDDEHRDELQRLAWIGLMDQAR
ADLGSDGLKTWWKNQSRKTRQQVPLQVAMAEHLIECDDHDTAQEILLDGLKRQYDDRLVM
VIPRLKTNNPEQIEKMLRQQIKAVGDRPLLWSTLGQSLMKHGEWQEASLAFRAALKQRPD
AFDYAWLADSLDKQHKPEEAAAMRRDGLLLTLQNNGSQQ