Protein Info for MPMX20_04286 in Enterobacter sp. TBS_079

Annotation: Intracellular growth attenuator protein igaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 711 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 207 to 224 (18 residues), see Phobius details amino acids 230 to 248 (19 residues), see Phobius details amino acids 339 to 360 (22 residues), see Phobius details amino acids 653 to 678 (26 residues), see Phobius details PF07095: IgaA" amino acids 1 to 705 (705 residues), 1139.6 bits, see alignment E=0

Best Hits

Swiss-Prot: 78% identical to IGAA_ECOLI: Putative membrane protein IgaA homolog (yrfF) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 95% identity to enc:ECL_04761)

Predicted SEED Role

"IgaA: a membrane protein that prevents overactivation of the Rcs regulatory system"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (711 amino acids)

>MPMX20_04286 Intracellular growth attenuator protein igaA (Enterobacter sp. TBS_079)
MSTILIVLAAMLAGALVAGWVYRRRVRRRYRLPFLNAFAGATTRKLTQEERDAVENYLET
LNRSQLTPGPTGATAAPVALKLNAQSDTVLSVTRSITRYGITTDDPNKWRYYLDSVEVHL
PPSWEQYINDENSVELIHTDSLPLVISLNGHTLNEYLQEAPRFALERASSTQASIRGEET
EQIELLNIRQETHEEYALSRPDGIREAILIVAAFLLFFICLLTPDVFVPWLAGGAVLLLA
AGLWGLFAPPAKTSLREIHCLRGTPKRWGLFGESDQEHLNNISLGIIDLIYPRHWQPWIA
QDLGQKTDIDIYLDRHVVRQGRFLSLHDEVKNFPLQHWLRSAVIAGGAALVFIMLLLFVP
LDMPIKFTLSWIKGAQTIEATSVNQLDEAGVRVGDTLRLKGTGMCNIHTPGAWNTRQSSP
FMPFDCSQIIWNDAPPLPLPESEVVNKATSLTQTVNRQLHPKPDDDSRVSPALRSAIQKS
GMVLLDDFGDIVLKTQDLCSAQDECVRLKNALVNLGNSKDWDSLVKRAEAGRLDGVNVLL
RPVSAESLDNLVATSTAPFVMRETTRAAQALNSPAPGGFVIVSDEGSDLVDQPYPQVALY
DYPAQEQWGQFQRLAQMLMQTPFSAEGIVTSIFTDANGTRHIGLHRMPDSAGLWRYIGTS
LLMIAMLVCICWNGFMALRRYQRSRTRLADIQQYYENCLNPKLIPSSESLI