Protein Info for MPMX20_03855 in Enterobacter sp. TBS_079
Annotation: Alcohol dehydrogenase YqhD
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 89% identical to YQHD_ECOLI: Alcohol dehydrogenase YqhD (yqhD) from Escherichia coli (strain K12)
KEGG orthology group: K08325, NADP-dependent alcohol dehydrogenase [EC: 1.1.-.-] (inferred from 97% identity to enc:ECL_04334)MetaCyc: 89% identical to NADPH-dependent aldehyde reductase YqhD (Escherichia coli K-12 substr. MG1655)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]
Predicted SEED Role
"Hypothetical oxidoreductase YqhD (EC 1.1.-.-)" in subsystem D-gluconate and ketogluconates metabolism (EC 1.1.-.-)
MetaCyc Pathways
- superpathway of methylglyoxal degradation (7/8 steps found)
- methylglyoxal degradation III (2/2 steps found)
- 1,3-propanediol biosynthesis (engineered) (7/9 steps found)
- glycerol degradation to butanol (12/16 steps found)
- D-xylose degradation to ethylene glycol (engineered) (3/4 steps found)
- D-arabinose degradation V (1/3 steps found)
- D-galactose degradation IV (1/3 steps found)
- pyruvate fermentation to butanol I (4/8 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
- detoxification of reactive carbonyls in chloroplasts (1/10 steps found)
- superpathway of pentose and pentitol degradation (16/42 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Benzoate degradation via CoA ligation
- Bisphenol A degradation
- Caprolactam degradation
- Ethylbenzene degradation
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Glycolysis / Gluconeogenesis
- Limonene and pinene degradation
- Naphthalene and anthracene degradation
- Pentose and glucuronate interconversions
- Pyruvate metabolism
- Retinol metabolism
- gamma-Hexachlorocyclohexane degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.-.-
Use Curated BLAST to search for 1.1.-.- or 1.1.1.2 or 1.1.1.21
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (387 amino acids)
>MPMX20_03855 Alcohol dehydrogenase YqhD (Enterobacter sp. TBS_079) MNNFNLHTPTRILFGKGAIADLRAQIPADARVLITYGGGSVKKTGVLDQVYSALEGLDVR EFGGIEPNPSYETLMNAVNIARDEKVTFLLAVGGGSVLDGTKFIAAAAHYADGIDPWHIL ETRGSDIKSAIPMGSVLTLPATGSESNKGAVISRKTTGDKQAFMNDHVQPVFAILDPVYT YTLPARQVANGVVDAFVHTVEQYVTYPVDAKIQDRFAEGILLTLIEDGPTALKEPENYDV RANVMWAATQALNGLIGAGVPQDWATHMLGHELTAMHGLDHAQTLAVVLPALWNEKRDTK RAKLLQYAERVWNITEGSDDARIDAAIEATRSFFEGLGVPTRLSGYGLDGSSIPALLAKL EEHGMTQLGEHGDITLEVSRRIYEAAR