Protein Info for MPMX20_03827 in Enterobacter sp. TBS_079

Annotation: [Citrate [pro-3S]-lyase] ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 341 TIGR00124: [citrate (pro-3S)-lyase] ligase" amino acids 19 to 334 (316 residues), 393.2 bits, see alignment E=9.1e-122 PF00583: Acetyltransf_1" amino acids 34 to 105 (72 residues), 22.2 bits, see alignment E=2.2e-08 TIGR00125: cytidyltransferase-like domain" amino acids 150 to 208 (59 residues), 35.6 bits, see alignment E=8.5e-13 PF08218: Citrate_ly_lig" amino acids 150 to 330 (181 residues), 255.4 bits, see alignment E=4.1e-80 PF01467: CTP_transf_like" amino acids 158 to 245 (88 residues), 24 bits, see alignment E=6e-09

Best Hits

Swiss-Prot: 48% identical to CITC_KLEPN: [Citrate [pro-3S]-lyase] ligase (citC) from Klebsiella pneumoniae

KEGG orthology group: K01910, [citrate (pro-3S)-lyase] ligase [EC: 6.2.1.22] (inferred from 94% identity to enc:ECL_04298)

MetaCyc: 48% identical to [citrate [pro-3S]-lyase] ligase (Klebsiella pneumoniae)
[Citrate (pro-3S)-lyase] ligase. [EC: 6.2.1.22]

Predicted SEED Role

"[Citrate [pro-3S]-lyase] ligase (EC 6.2.1.22)" (EC 6.2.1.22)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (341 amino acids)

>MPMX20_03827 [Citrate [pro-3S]-lyase] ligase (Enterobacter sp. TBS_079)
MNSQPTIDFRHTLVAKHPERLSQIRYLLADSGLGLDNDITLFVEAWSGTQLVGCAGLAAN
VIKCVAVNEQLRGENLSARLLAEVENAALERGHFHLFLCTRPCNKERFGRSGFWPIAQSG
NNAVLMENTPQGIQRYCRALKCQRKAGKKIGAIVMNANPFTLGHRHLVEQAAGQCDALHL
FVVREDASFFPFSARLEMVRAGVAHLPNVIVHEGSQYIISRATFPAYFLKETGKVQQAWS
EIDVLIFRDFIAPALGITHRFIGSEPFCDITRQYNQTLHDLLASQIDVVEMPRIKVTGNA
ISASEVRRLLKTQQFSRIREIVPDSTFAHLETHYRASAEVA