Protein Info for MPMX20_03812 in Enterobacter sp. TBS_079

Annotation: dITP/XTP pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00042: non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
  • amino acids 3 to 194 (192 residues), 233 bits, E=8.5e-74
• PF01725: Ham1p_like
  • amino acids 4 to 192 (189 residues), 224.4 bits, E=5.7e-71

Best Hits

Swiss-Prot: 92% identical to IXTPA_SALPA: dITP/XTP pyrophosphatase (rdgB) from Salmonella paratyphi A (strain ATCC 9150 / SARB42)

KEGG orthology group: None (inferred from 94% identity to eae:EAE_03155)

MetaCyc: 89% identical to dITP/XTP pyrophosphatase (Escherichia coli K-12 substr. MG1655)
Nucleotide diphosphatase. [EC: 3.6.1.66, 3.6.1.9]; 3.6.1.66 [EC: 3.6.1.66, 3.6.1.9]; 3.6.1.66 [EC: 3.6.1.66, 3.6.1.9]

Predicted SEED Role

"Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15)" in subsystem Heat shock dnaK gene cluster extended (EC 3.6.1.15)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (14/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (7/7 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• pyrimidine deoxyribonucleotides dephosphorylation (3/3 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• dZTP biosynthesis (3/5 steps found)
• tunicamycin biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism
• Pantothenate and CoA biosynthesis
• Purine metabolism
• Riboflavin metabolism
• Starch and sucrose metabolism
• Thiamine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.15 or 3.6.1.66 or 3.6.1.9

Protein Sequence (197 amino acids)

>MPMX20_03812 dITP/XTP pyrophosphatase (Enterobacter sp. TBS_079)
MQKVVLATGNAGKVRELASLLNDFGLDVVAQTELGVDSAEETGLTFIENAILKARHAAQI
TGLPAIADDSGLAVDALGGAPGIYSARYSGVDATDQQNLEKLLVALKDVPDDKRQAQFHC
VLVYLRHAEDPTPVVCHGSWPGVITREAAGSGGFGYDPIFFVPSEGKTAAELSREEKSAI
SHRGRALKLLLEALRNG