Protein Info for MPMX20_03564 in Enterobacter sp. TBS_079

Annotation: Multidrug export protein EmrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 515 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 55 to 75 (21 residues), see Phobius details amino acids 84 to 103 (20 residues), see Phobius details amino acids 109 to 131 (23 residues), see Phobius details amino acids 143 to 164 (22 residues), see Phobius details amino acids 170 to 192 (23 residues), see Phobius details amino acids 204 to 223 (20 residues), see Phobius details amino acids 235 to 254 (20 residues), see Phobius details amino acids 275 to 295 (21 residues), see Phobius details amino acids 306 to 327 (22 residues), see Phobius details amino acids 339 to 356 (18 residues), see Phobius details amino acids 370 to 393 (24 residues), see Phobius details amino acids 483 to 501 (19 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 16 to 501 (486 residues), 714.6 bits, see alignment E=3e-219 PF07690: MFS_1" amino acids 22 to 417 (396 residues), 187.6 bits, see alignment E=3.1e-59 PF06609: TRI12" amino acids 25 to 429 (405 residues), 41.3 bits, see alignment E=7.7e-15

Best Hits

Swiss-Prot: 92% identical to EMRB_ECOLI: Multidrug export protein EmrB (emrB) from Escherichia coli (strain K12)

KEGG orthology group: K03446, MFS transporter, DHA2 family, multidrug resistance protein B (inferred from 96% identity to enc:ECL_04023)

MetaCyc: 92% identical to multidrug efflux pump membrane subunit EmrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-363; TRANS-RXN-364; TRANS-RXN-365

Predicted SEED Role

"Multidrug resistance protein B"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (515 amino acids)

>MPMX20_03564 Multidrug export protein EmrB (Enterobacter sp. TBS_079)
MQQQKPQKPLEGAQLVIMTIALSLATFMQVLDSTIANVAIPTIAGNLGSSLSQGTWVITS
FGVANAISIPITGWLAKRVGEVKLFLWSTVLFVLASWACGMSNSLTMLIIFRVIQGIVAG
PLIPLSQSLLLNNYPPAKRSIALALWSMTVIVAPICGPILGGYISDNYHWGWIFFINVPI
GALVVMLTLQTLRGRETRTEQRRIDAIGLALLVVGIGSLQVMLDQGKELDWFNSTEIIIL
TVVAVISLSFLIVWELTDDNPIVDLSLFKSRNFTIGCLCISLAYMLYFGAIVLLPQLLQE
VYGYTATWAGLASAPVGLIPVLLSPIIGRFAHKLDMRRLVTFSFIMYAVCFYWRAYTFEP
GMDFGASAWPQFIQGFAVACFFMPLTTITLSGLPPERMAAASSLSNFTRTLAGSIGTSIT
TTLWTNRESMHHAQLTEAVNPFNPNSQQMYSQLQGMGMTEQQASGWIAQQITNQGLIISA
NEIFWISAGIFIILLGLVWFARPPFGAGGGGGGAH