Protein Info for MPMX20_03404 in Enterobacter sp. TBS_079

Annotation: Peptidase B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 PF12404: DUF3663" amino acids 5 to 80 (76 residues), 106.5 bits, see alignment E=5.6e-35 PF00883: Peptidase_M17" amino acids 109 to 421 (313 residues), 352.6 bits, see alignment E=2e-109

Best Hits

Swiss-Prot: 96% identical to PEPB_ENT38: Peptidase B (pepB) from Enterobacter sp. (strain 638)

KEGG orthology group: K07751, PepB aminopeptidase [EC: 3.4.11.23] (inferred from 97% identity to enc:ECL_03872)

MetaCyc: 88% identical to aminopeptidase B (Escherichia coli K-12 substr. MG1655)
Cytosol nonspecific dipeptidase. [EC: 3.4.13.18]; PepB aminopeptidase. [EC: 3.4.13.18, 3.4.11.23]

Predicted SEED Role

"Peptidase B (EC 3.4.11.23)" (EC 3.4.11.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.23 or 3.4.13.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (428 amino acids)

>MPMX20_03404 Peptidase B (Enterobacter sp. TBS_079)
MTEAMKITISNQPADARWGEKATYSINNDGITLHLTGNDDLGLIQRAARKIDGLGIKHVT
LDGEGWDIDRSWAFWAGYKGPKGSRKIEWATLDEAGQKELESRLTIIDWVRDTINAPAEE
LGPEQLAQRAVDLLCGVAGDKMSYRITKGEDLREQNYMGIHTVGRGSERPPVLLALDYNP
TGDKAAPVFACLVGKGITFDTGGYSLKQSAFMDSMKSDMGGAATITGALAFAITRGLNKR
VKLYLCCADNMVSGNAFKLGDIIRYRNGKNVEVMNTDAEGRLVLADGLIDASAQKPELII
DMATLTGAAKTALGNDYHALFSFDDKLAARLLASAAAENEPFWRLPLAEFHRSQLPSNFA
ELNNTASAAYPAGASTAAGFLSHFVENYHEGWLHIDCSATYRKAAVEQWSAGATGLGVRT
IANLLTAE