Protein Info for MPMX20_02697 in Enterobacter sp. TBS_079

Annotation: K(+)/H(+) antiporter NhaP2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 577 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 31 to 53 (23 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 89 to 116 (28 residues), see Phobius details amino acids 122 to 142 (21 residues), see Phobius details amino acids 185 to 209 (25 residues), see Phobius details amino acids 222 to 255 (34 residues), see Phobius details amino acids 273 to 291 (19 residues), see Phobius details amino acids 298 to 323 (26 residues), see Phobius details amino acids 335 to 356 (22 residues), see Phobius details amino acids 363 to 385 (23 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 15 to 388 (374 residues), 212.7 bits, see alignment E=1.2e-66 PF02080: TrkA_C" amino acids 420 to 483 (64 residues), 48.8 bits, see alignment E=7.6e-17 PF03471: CorC_HlyC" amino acids 494 to 572 (79 residues), 43.5 bits, see alignment E=3.8e-15

Best Hits

Swiss-Prot: 97% identical to NHAP2_ENT38: K(+)/H(+) antiporter NhaP2 (nhaP2) from Enterobacter sp. (strain 638)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 97% identity to ent:Ent638_2361)

Predicted SEED Role

"Cell volume regulation protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (577 amino acids)

>MPMX20_02697 K(+)/H(+) antiporter NhaP2 (Enterobacter sp. TBS_079)
MDAAAIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGIDGIGGIPFDNYPF
AYMVSNLALAVILLDGGMRTQASSFRVALGPALSLATVGVLITSGLTGMMAAWLFHLNIM
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIEMIQQHE
SGLSWMFAWHILQQFGLGIILGLGGGYLLQQMINRISLPAGLYPLLALSGGILIFAVTTA
LDGSGILAVYLCGFLMGNRPIRNRHAILQNFDGLAWLAQIGMFLVLGLLVTPSDLLPIAV
PALMLSAWMIFFARPLSVFAGLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLDN
ARLFFNVAFFVVLISLLFQGTSLGWAAKKAKVVIPPVGWPVSRVGLDIHPENPWEQFVYQ
LSEDKWCVGASLRDLHMPTETRIAALFRDNVLLHPTGSTRLREGDILCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEASAKFADVALIYGLDEGLEYRDKQQTLGEIIQQLLGAA
PVVGDQVEFAGMIWTVAEKEDNAVRKVGVRPMEEESE