Protein Info for MPMX20_02497 in Enterobacter sp. TBS_079

Annotation: Phosphatidylglycerophosphatase B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01569: PAP2
  • amino acids 81 to 230 (150 residues), 95.6 bits, E=1.1e-31

Best Hits

Swiss-Prot: 79% identical to PGPB_SHIFL: Phosphatidylglycerophosphatase B (pgpB) from Shigella flexneri

KEGG orthology group: K01096, phosphatidylglycerophosphatase B [EC: 3.1.3.27] (inferred from 94% identity to enc:ECL_01745)

MetaCyc: 79% identical to phosphatidylglycerophosphatase B (Escherichia coli K-12 substr. MG1655)
RXN-11277 [EC: 3.6.1.75]; Undecaprenyl-diphosphatase. [EC: 3.6.1.75, 3.6.1.27]; Phosphatidylglycerophosphatase. [EC: 3.6.1.75, 3.6.1.27, 3.1.3.27]

Predicted SEED Role

"Phosphatidylglycerophosphatase B (EC 3.1.3.27)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 3.1.3.27)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (11/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• polyisoprenoid biosynthesis (E. coli) (5/5 steps found)
• cardiolipin biosynthesis I (3/3 steps found)
• cardiolipin biosynthesis II (3/3 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• di-trans,poly-cis-undecaprenyl phosphate biosynthesis (2/2 steps found)
• cardiolipin biosynthesis III (2/3 steps found)
• phosphatidate metabolism, as a signaling molecule (2/5 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism
• Peptidoglycan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.27

Use Curated BLAST to search for 3.1.3.27 or 3.6.1.27 or 3.6.1.75

Protein Sequence (255 amino acids)

>MPMX20_02497 Phosphatidylglycerophosphatase B (Enterobacter sp. TBS_079)
MLSIARRTAAGAAILLIMPLAVWVSGWMWQPGQNATWLKTLYWITETVTQPWGIITHVIL
CAWFLWCLRFRLRAALMLFAILGGAILIGQGVKSWVKDHVQEPRPFVVWLEKAHHVPVDE
FYNLKRKDRGALVKEQLAEQQDIPKFLRKHWQKETGFAFPSGHTMFAASWALLGVGLLWP
RRRTVTIAILLVWATGVMGSRLLLGMHWPRDLVVATLISWLLVTLATWLAERICGPLTPP
PVEEEEIAERDQSDA