Protein Info for MPMX20_02454 in Enterobacter sp. TBS_079

Annotation: Transcriptional regulatory protein TyrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 PF00158: Sigma54_activat" amino acids 206 to 365 (160 residues), 190.1 bits, see alignment E=5.1e-60 PF14532: Sigma54_activ_2" amino acids 209 to 370 (162 residues), 71 bits, see alignment E=2.6e-23 PF00004: AAA" amino acids 230 to 344 (115 residues), 22.1 bits, see alignment E=3.6e-08 PF18024: HTH_50" amino acids 458 to 507 (50 residues), 67.4 bits, see alignment 1.4e-22 TIGR04381: TyrR family helix-turn-helix domain" amino acids 460 to 507 (48 residues), 96 bits, see alignment 5e-32

Best Hits

Swiss-Prot: 88% identical to TYRR_SALTY: Transcriptional regulatory protein TyrR (tyrR) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03721, transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport (inferred from 98% identity to enc:ECL_01794)

Predicted SEED Role

"Transcriptional repressor protein TyrR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>MPMX20_02454 Transcriptional regulatory protein TyrR (Enterobacter sp. TBS_079)
MRLEVFCEDRLGLTRELLDLLVLRSIDLRGIEIDPVGRIYLNFAEIEFNTFSSLMAEIRR
IAGVTDVRTIPWMPSEREHLALSALLEAMPEPFLSLDLKSKVERVNHASCQLFAQSQEKL
SNHNAAQLIPGFNFQRWLDSNPQNTHSEHVVIHGQNFLMEITPVYLKGEADTRVLTGAVI
MLRSTVRMGRQLQNISSQDVGAFSQIIAVSPKMRHVVDQARKLASLTAPLLITGDTGTGK
DLLAHAVHLASPRAAKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
GEMSPRMQAKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGVFREDLYYRL
NVLTLNIPPLRDCPEDIMPLTELFVARFADEQGVPRPKLSADLGTVLMRYGWPGNIRQLK
NAVYRALTQLEGYELRPQDILLPDYDAGTVSVGEEAMEGSLDDITSRFERSVLTQLYRSY
PSTRKLAKRLGVSHTAIANKLREYGLNQKKGDE