Protein Info for MPMX20_02410 in Enterobacter sp. TBS_079

Annotation: NADPH-dependent curcumin reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16884: ADH_N_2
  • amino acids 9 to 116 (108 residues), 151.2 bits, E=1.3e-48
• PF00107: ADH_zinc_N
  • amino acids 161 to 296 (136 residues), 68.7 bits, E=7.3e-23
• PF13602: ADH_zinc_N_2
  • amino acids 194 to 339 (146 residues), 49.1 bits, E=1.8e-16

Best Hits

Swiss-Prot: 83% identical to CURA_ECOLI: NADPH-dependent curcumin reductase (curA) from Escherichia coli (strain K12)

KEGG orthology group: K07119, (no description) (inferred from 92% identity to enc:ECL_01865)

MetaCyc: 83% identical to NADPH-dependent curcumin/dihydrocurcumin reductase (Escherichia coli K-12 substr. MG1655)
RXN0-6676; RXN0-6677

Predicted SEED Role

"Putative oxidoreductase YncB"

MetaCyc Pathways

• curcumin degradation (2/2 steps found)

Protein Sequence (346 amino acids)

>MPMX20_02410 NADPH-dependent curcumin reductase (Enterobacter sp. TBS_079)
MNQSVSQNRRWVLASRPHGAPVAENFRLEEQPVPEPQAGQLLLRTVWLSLDPYMRGRMSD
APSYSPPVEIGAVMVGGTVSRVEQSNHPDYTPGEWVLGYSGWQEYAISDGSGLVKLGDNI
SHPSWALGILGMPGFTAYMGLLDIGQPKAGETLVVAAATGPVGATVGQIGKIKGCRVIGV
AGGAEKCRHAVEVLGFDQCLDHHADDFAAQLEKACPKGIDVYYENVGGKVFDAVLPLLNT
SARVPVCGLVSGYNATGLPEGPDRLPLLMATILKKRIRMQGFIIAQDYGHRIKEFQDEMG
RWVQEGKIHYREQVTDGLENAPEALIGLLEGKNFGKVVIRVAGDNK