Protein Info for MPMX20_01956 in Enterobacter sp. TBS_079

Annotation: Methionine import system permease protein MetP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 222 transmembrane" amino acids 22 to 45 (24 residues), see Phobius details amino acids 57 to 81 (25 residues), see Phobius details amino acids 87 to 110 (24 residues), see Phobius details amino acids 150 to 175 (26 residues), see Phobius details amino acids 194 to 218 (25 residues), see Phobius details PF00528: BPD_transp_1" amino acids 44 to 222 (179 residues), 70.6 bits, see alignment E=7.5e-24

Best Hits

Swiss-Prot: 68% identical to METP_BACSU: Methionine import system permease protein MetP (metP) from Bacillus subtilis (strain 168)

KEGG orthology group: K02072, D-methionine transport system permease protein (inferred from 97% identity to enc:ECL_02358)

MetaCyc: 48% identical to L-methionine/D-methionine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
RXN0-4522 [EC: 7.4.2.11]; 7.4.2.11 [EC: 7.4.2.11]; TRANS-RXN-383 [EC: 7.4.2.11]; TRANS-RXN0-510 [EC: 7.4.2.11]; TRANS-RXN0-511 [EC: 7.4.2.11]

Predicted SEED Role

"Methionine ABC transporter permease protein" in subsystem Methionine Biosynthesis or Methionine Degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (222 amino acids)

>MPMX20_01956 Methionine import system permease protein MetP (Enterobacter sp. TBS_079)
MAETLFPHLKWEQLWAATLETLYMTALSGVATFVLGIVLGLALFLTARGGLFHNRAVYSV
ISIVVNVFRSIPFIILIVLLIPFTKTLVGTILGANAALPALIVGAAPFYARLVEIALREV
DKGVIEATRSMGARLSTLVFRVLLPESSPALVSGITVTLIALVSYSAMAGVIGAGGLGNL
AYLEGFQRNHGDVTLVATVTILIIVFIIQFCGDVLTSLLDKR