Protein Info for MPMX20_01810 in Enterobacter sp. TBS_079

Annotation: Virulence sensor histidine kinase PhoQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 487 transmembrane" amino acids 17 to 42 (26 residues), see Phobius details amino acids 194 to 217 (24 residues), see Phobius details PF08918: PhoQ_Sensor" amino acids 10 to 189 (180 residues), 286.3 bits, see alignment E=2.1e-89 PF00672: HAMP" amino acids 213 to 262 (50 residues), 24.5 bits, see alignment 5.7e-09 PF02518: HATPase_c" amino acids 377 to 477 (101 residues), 67 bits, see alignment E=4e-22 PF14501: HATPase_c_5" amino acids 377 to 464 (88 residues), 30.8 bits, see alignment E=4.8e-11

Best Hits

Swiss-Prot: 82% identical to PHOQ_SALPA: Virulence sensor histidine kinase PhoQ (phoQ) from Salmonella paratyphi A (strain ATCC 9150 / SARB42)

KEGG orthology group: K07637, two-component system, OmpR family, sensor histidine kinase PhoQ [EC: 2.7.13.3] (inferred from 95% identity to enc:ECL_02505)

MetaCyc: 82% identical to sensor histidine kinase PhoQ (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Sensor protein PhoQ (EC 2.7.13.3)" in subsystem Lipid A modifications (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (487 amino acids)

>MPMX20_01810 Virulence sensor histidine kinase PhoQ (Enterobacter sp. TBS_079)
MKGILRHILPLSLRVRFLLATAAVVLVLSLSYGMVALVGYSVSFDKTTFRLLRGESNLFY
TLAKWENNTITVEMPENLNQQSPTLALIYNEKGKLLWAQRDIPWLVKSIRPEWLKTNGFH
ELEADLNTTSSLLREDRSLQQKLNEIRADDAETEMTHSVAINLYPATMNMPQLTIVVVDT
IPVELKRSYMVWNWFVYVLAANLLLVIPLLWLAAWWSLRPIESLAREVRELEEHHREKLN
PDTTRELTSLVRNLNRLLKSERERYDKYRTTLTDLTHSLKTPLAVMQSTLRSMRSSKLSV
DDAEPVMLEQISRISQQIGYYLHRASMRSGSALLSRELHTVAPLLDNLTSALNKVYQRKG
VNISLDISPEISFVGEKNDFMEVMGNLLDNACKYCLEFVEVSARQTDNELHIIVEDDGPG
IPRNKRDVVFDRGQRADTLRPGQGVGLAVAREIVDQYDGKIETEDSLLGGARMEVIFGRQ
QPISNDS