Protein Info for MPMX20_01436 in Enterobacter sp. TBS_079

Annotation: Ribosomal RNA large subunit methyltransferase F

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05971: Methyltransf_10
  • amino acids 4 to 297 (294 residues), 460.6 bits, E=2.5e-142
• PF05175: MTS
  • amino acids 105 to 196 (92 residues), 24 bits, E=2.8e-09

Best Hits

Swiss-Prot: 84% identical to RLMF_ENT38: Ribosomal RNA large subunit methyltransferase F (rlmF) from Enterobacter sp. (strain 638)

KEGG orthology group: K06970, ribosomal RNA large subunit methyltransferase F [EC: 2.1.1.181] (inferred from 91% identity to enc:ECL_02924)

MetaCyc: 76% identical to 23S rRNA m6A1618 methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-11596 [EC: 2.1.1.181]

Predicted SEED Role

"Ribosomal RNA large subunit methyltransferase F (EC 2.1.1.51)" (EC 2.1.1.51)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.51

Use Curated BLAST to search for 2.1.1.181 or 2.1.1.51

Protein Sequence (303 amino acids)

>MPMX20_01436 Ribosomal RNA large subunit methyltransferase F (Enterobacter sp. TBS_079)
MTSQKPGLHPRNRHRNRYDMNALCQSCPSLQDYIVQTPAGEPSVNFADPQAVKMLNKALL
AHYYGVAHWDIPEGFLCPPVPGRADYLHHLADLLADDRNGVIPEQASVLDIGTGANLIYP
LIGVHEYHWRFTGSEIGNEAFSSAQAIINANPGLSRSVRLRRQKDAASIFNGIIHKNESY
DATLCNPPFHDSAATARAGSERKRRNLGQAEDAALNFGGQQQELWCEGGEVAFILRMIEE
SKVFGRQVKWFTTLVSRGDNLPPLYRALTDVGAVNVVKKEMAQGQKQSRFIAWSFMDANK
RSK