Protein Info for MPMX20_01422 in Enterobacter sp. TBS_079

Annotation: putative multidrug ABC transporter ATP-binding protein YbhF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 579 PF00005: ABC_tran" amino acids 25 to 165 (141 residues), 96.4 bits, see alignment E=5.8e-31 amino acids 346 to 489 (144 residues), 101.9 bits, see alignment E=1.2e-32 PF13304: AAA_21" amino acids 463 to 518 (56 residues), 27.3 bits, see alignment 8.9e-10

Best Hits

Swiss-Prot: 90% identical to YBHF_SHIFL: Probable multidrug ABC transporter ATP-binding protein YbhF (ybhF) from Shigella flexneri

KEGG orthology group: K01990, ABC-2 type transport system ATP-binding protein (inferred from 96% identity to enc:ECL_02941)

MetaCyc: 90% identical to ABC exporter ATP binding subunit YbhF (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-366 [EC: 7.6.2.2]

Predicted SEED Role

"ABC transporter multidrug efflux pump, fused ATP-binding domains"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (579 amino acids)

>MPMX20_01422 putative multidrug ABC transporter ATP-binding protein YbhF (Enterobacter sp. TBS_079)
MNDAVIQLNNLVKRFAGMEKPAVAPLNCTIQKGYVTGLVGPDGAGKTTLMRMLAGLLKPD
EGTASVLGLDPIKDDGALHAMLGYMPQKFGLYEDLTVMENLNLYADLRSVTGEARQKTFA
RLLEFTSLGPFTDRLAGKLSGGMKQKLGLACTLVGEPKVLLLDEPGVGVDPISRRELWQM
VHELAGDGMLILWSTSYLDEAEQCRDVLLMNEGELLYQGEPTTLTQSMAGRSFLLHSAQA
SNRQLLQRVLKLPQVSDGMIQGRSVRVILTKEATADDIRRAPGMPEIEMEETAPRFEDAF
IDLLGGAGTSESPLAAILHTVEGTPGETVIEAKSLTKKFGDFAATDNVNFAVKRGEIFGL
LGPNGAGKSTTFKMMCGLLVPTSGKALVLDMDLKVSSGKARQHLGYMAQKFSLYGNLTVE
QNLRFFSGVYGLRGRAQNEKIHRMSEAFGLTGIASHATDELPLGFKQRLALACSLMHEPD
ILFLDEPTSGVDPLTRREFWLHINSMVEKGVTVMVTTHFMDEAEYCDRIGLVYRGKLIAH
GTPDDLKEQAADDEVPDPTMEQAFITLIHDWDKENAHAQ