Protein Info for MPMX20_01398 in Enterobacter sp. TBS_079

Annotation: HTH-type transcriptional repressor NagR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 244 TIGR02018: histidine utilization repressor" amino acids 15 to 243 (229 residues), 348.7 bits, see alignment E=6.5e-109 PF00392: GntR" amino acids 17 to 79 (63 residues), 80.7 bits, see alignment E=7.5e-27 PF07702: UTRA" amino acids 101 to 237 (137 residues), 129.2 bits, see alignment E=1.6e-41

Best Hits

Swiss-Prot: 81% identical to HUTC_KLEAE: Histidine utilization repressor (hutC) from Klebsiella aerogenes

KEGG orthology group: K05836, GntR family transcriptional regulator, histidine utilization repressor (inferred from 92% identity to enc:ECL_02966)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (244 amino acids)

>MPMX20_01398 HTH-type transcriptional repressor NagR (Enterobacter sp. TBS_079)
MFSRSPLSQSSPPAPFYEKVKQAISEKIATGVWRPHDRIPSEAELVAQFGFSRMTINRAL
RELTDEGLLVRLQGVGTFVAEPKGQSALFEIRSIADEIASRNHQHHCEVLVLEETQASAE
QAVELNVKEGSRIFHSVMVHYENDIPVQIEDRCVNAGRVPEYLDQDYTQTTPHAYLSLIA
PLTEGEHIVEAVRATPQECELLRIKEHDPCLLIRRRTWSSSHIVSHARLLFPGNRYRLQG
HFMS