Protein Info for MPMX20_01359 in Enterobacter sp. TBS_079

Annotation: PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 638 transmembrane" amino acids 290 to 316 (27 residues), see Phobius details amino acids 337 to 356 (20 residues), see Phobius details amino acids 368 to 394 (27 residues), see Phobius details amino acids 414 to 434 (21 residues), see Phobius details amino acids 446 to 467 (22 residues), see Phobius details amino acids 478 to 498 (21 residues), see Phobius details amino acids 503 to 520 (18 residues), see Phobius details amino acids 532 to 547 (16 residues), see Phobius details amino acids 555 to 578 (24 residues), see Phobius details amino acids 596 to 621 (26 residues), see Phobius details PF00359: PTS_EIIA_2" amino acids 7 to 149 (143 residues), 103.2 bits, see alignment E=1.3e-33 TIGR00848: PTS system, fructose subfamily, IIA component" amino acids 7 to 134 (128 residues), 118.8 bits, see alignment E=2.2e-38 TIGR00829: PTS system, Fru family, IIB component" amino acids 167 to 246 (80 residues), 78.5 bits, see alignment E=5.6e-26 PF02302: PTS_IIB" amino acids 168 to 258 (91 residues), 66.5 bits, see alignment E=2.8e-22 TIGR01427: PTS system, Fru family, IIC component" amino acids 275 to 622 (348 residues), 264.6 bits, see alignment E=2.3e-82

Best Hits

Swiss-Prot: 80% identical to MNGA_ECOLI: PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component (mngA) from Escherichia coli (strain K12)

KEGG orthology group: K11198, PTS system, 2-O-A-mannosyl-D-glycerate-specific IIA component [EC: 2.7.1.69] K11199, PTS system, 2-O-A-mannosyl-D-glycerate-specific IIB component [EC: 2.7.1.69] K11200, PTS system, 2-O-A-mannosyl-D-glycerate-specific IIC component (inferred from 86% identity to enc:ECL_03001)

MetaCyc: 80% identical to 2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II (Escherichia coli K-12 substr. MG1655)
RXN0-2522 [EC: 2.7.1.195]

Predicted SEED Role

"PTS system, 2-O-alpha-mannosyl-D-glycerate-specific IIA component / PTS system, 2-O-alpha-mannosyl-D-glycerate-specific IIB component / PTS system, 2-O-alpha-mannosyl-D-glycerate-specific IIC component"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.195 or 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (638 amino acids)

>MPMX20_01359 PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component (Enterobacter sp. TBS_079)
MNLTTLTHPDAVCVQAQYTSRDEAIRQLTMRLVTLGKITDGNAFLTEVFHRESLGPTALG
EGLAVPHGKSAVVKEAAFAVATLCEPLSWEGVDGPENVELIFLLAIPPAEAGSTHIQVLT
ELTSRLADETLRARVMAATTAAALLAALDDVPQEDDVVAFVDAPTIVCVTACPAGIAHTY
MAAEYLEKAGRKLGVNVVVEKQGANGIEGRLTAQQLRTAQACIIAAEVALKESERFQGIP
TLSVPVAEPLRHAEALIKRALALPPAETDRQVHTGNDVSKSLKTELKQALLSGISFAVPL
IVAGGTVLAVAVLLAQMLGLQHLFEQENSWLWMYRKLGGGMLGTLMVPVLAAYTAYSLAD
KPALAPGFAAGLAANMIGSGFLGAIAGGLIAGYLMRWVKNHIRLSQRYNGFLTYYLYPVI
GVLGAGSLMLFVIGEPVAWINTSLTAWLNGLSGANALLLGTLLGFMCSFDLGGPVNKAAY
AFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPHLFKPFEIETGKSTWLLGLAGIT
EGAIPMAIEDPLRVIGSFVVGSMATGAIIGAMGIGLSTPGAGIFSLFLLHDAGMGGAIAA
AGWFGAALAGTMLSTLILLFWRRQGVKKGKYLTEDVTP