Protein Info for MPMX20_01141 in Enterobacter sp. TBS_079

Annotation: Multidrug resistance protein MdtA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 353 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 23 to 351 (329 residues), 267.5 bits, see alignment E=6.8e-84 PF13533: Biotin_lipoyl_2" amino acids 48 to 95 (48 residues), 52.7 bits, see alignment 4.3e-18 PF16576: HlyD_D23" amino acids 50 to 267 (218 residues), 54 bits, see alignment E=2.2e-18

Best Hits

Swiss-Prot: 33% identical to MDTA_ENT38: Multidrug resistance protein MdtA (mdtA) from Enterobacter sp. (strain 638)

KEGG orthology group: None (inferred from 85% identity to enc:ECL_03150)

Predicted SEED Role

"Probable RND efflux membrane fusion protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (353 amino acids)

>MPMX20_01141 Multidrug resistance protein MdtA (Enterobacter sp. TBS_079)
MKFPLLFVLLALFQPAFAAAIPVRVAVVEQTPHAAERHVPGRIEAIHTVEIRARTEGVIT
QVHFRDGQYVKKGDVLFELDDAEPRAAVRLAQAEVKSAEATLRQAQQQLSRFESLGNSNA
ISRHDVDNARMQRDVASAALEQAKARLETRNVTLAYTRITSPIDGRVGHSQFHAGSLVNP
SSGVLVDVVQLDPIRIAFALEEGAFATKAGQHADISALKRAWQARIDSNGQRLSGELTSV
DNRIDPRTASVMLRAEFANPRHQLLPGGNVNVYLRPASAQPVLTVPAAAVQQNGEGFFAW
VVNAEGKAEKRPLKIAGQIGQQFEISSGLHPGERAITDGAQRVQPGAAVQILN