Protein Info for MPMX20_01084 in Enterobacter sp. TBS_079

Annotation: Copper-exporting P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 832 transmembrane" amino acids 186 to 204 (19 residues), see Phobius details amino acids 216 to 237 (22 residues), see Phobius details amino acids 249 to 271 (23 residues), see Phobius details amino acids 283 to 301 (19 residues), see Phobius details amino acids 435 to 457 (23 residues), see Phobius details amino acids 463 to 485 (23 residues), see Phobius details amino acids 776 to 795 (20 residues), see Phobius details amino acids 801 to 822 (22 residues), see Phobius details PF00403: HMA" amino acids 8 to 61 (54 residues), 43.1 bits, see alignment 1.1e-14 amino acids 103 to 158 (56 residues), 60.4 bits, see alignment 4.5e-20 TIGR01511: copper-translocating P-type ATPase" amino acids 232 to 825 (594 residues), 627.8 bits, see alignment E=3.9e-192 TIGR01525: heavy metal translocating P-type ATPase" amino acids 251 to 825 (575 residues), 598.3 bits, see alignment E=3.6e-183 TIGR01494: HAD ATPase, P-type, family IC" amino acids 290 to 793 (504 residues), 291.3 bits, see alignment E=2.2e-90 PF00122: E1-E2_ATPase" amino acids 319 to 499 (181 residues), 178.5 bits, see alignment E=2.5e-56 PF00702: Hydrolase" amino acids 517 to 729 (213 residues), 138.6 bits, see alignment E=8.5e-44 PF08282: Hydrolase_3" amino acids 703 to 762 (60 residues), 24.4 bits, see alignment 5.9e-09

Best Hits

Swiss-Prot: 88% identical to COPA_SALTY: Copper-exporting P-type ATPase (copA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 94% identity to enc:ECL_01253)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (832 amino acids)

>MPMX20_01084 Copper-exporting P-type ATPase (Enterobacter sp. TBS_079)
MSHTIDLTLDGLSCGHCVKRVKESLEQRPDVDSAEVTLDHAAVTGSASADALIDTIKQAG
YGAELSHPKAKPLAESSSPSEALTAATPELPVADDIDDSQQLLINGMSCASCVSRVQNAL
QAVPGVAQARVNLAERTALVMGSASAADLVQAVEKAGYGAEAIEDDLKRRERQQETAVAT
MKRFRWQAIVALLVGVPVMVWGMIGDNMMVTDDNRTLWLVIGLITLAVMVFAGGHFYSSA
WKSLKNRTATMDTLVALGTGAAWLYSMSVNVWPQWFPMEARHLYYEASAMIIGLINLGHM
LEARARQRSSKALERLLDLTPPTARVVTDAGEKNVPLAEVQPGMTLRLTTGDRVPVDGEI
TQGEAWFDEAMLTGEPVPQQKAQGDAIHAGTVVQDGSVLFTASAVGSHTTLSRIIRMVRQ
AQSSKPEIGQLADKISAIFVPVVVGIALLSAAIWYVFGPAPQIVYTLVIATTVLIIACPC
ALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVVAVITA
GITQDDALRLAAALEQGSSHPLAHAIIEKAGNASLPQVSNFRTLRGLGVSGTAEGHTLLL
GNQALLKEHGVETSALEQDLKAQASQGATPVLLAVDGKAAALLAIRDPLRQDSVQALQRL
HRAGYRLVMLTGDNPVTANAIAREAGIDEVIAGVLPDGKADAIKTLQSQGRQVAMVGDGI
NDAPALAQAEVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISKATLRNMKQNLLGAF
VYNTLGIPIAAGILWPLTGTLLNPVVAGAAMALSSITVVSNANRLLRFKPKD