Protein Info for MPMX20_00870 in Enterobacter sp. TBS_079

Annotation: Constitutive lysine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 14 to 124 (111 residues), 101.6 bits, E=4.7e-33
• PF01276: OKR_DC_1
  • amino acids 130 to 544 (415 residues), 631.6 bits, E=8.6e-194
• PF03711: OKR_DC_1_C
  • amino acids 570 to 700 (131 residues), 157.3 bits, E=3.9e-50

Best Hits

Swiss-Prot: 88% identical to DCLZ_ECOLI: Constitutive lysine decarboxylase (ldcC) from Escherichia coli (strain K12)

KEGG orthology group: K01582, lysine decarboxylase [EC: 4.1.1.18] (inferred from 98% identity to enc:ECL_00989)

MetaCyc: 88% identical to lysine decarboxylase 2 (Escherichia coli K-12 substr. MG1655)
Lysine decarboxylase. [EC: 4.1.1.18]

Predicted SEED Role

"Lysine decarboxylase 2, constitutive (EC 4.1.1.18)" in subsystem Lysine degradation (EC 4.1.1.18)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (16/17 steps found)
• superpathway of polyamine biosynthesis I (7/8 steps found)
• aminopropylcadaverine biosynthesis (3/3 steps found)
• L-lysine degradation X (5/6 steps found)
• cadaverine biosynthesis (1/1 steps found)
• L-lysine degradation I (5/7 steps found)
• bisucaberin biosynthesis (1/5 steps found)
• desferrioxamine B biosynthesis (1/5 steps found)
• desferrioxamine E biosynthesis (1/5 steps found)
• lupanine biosynthesis (1/5 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.18

Protein Sequence (710 amino acids)

>MPMX20_00870 Constitutive lysine decarboxylase (Enterobacter sp. TBS_079)
MNIIAIMGPHGVFYKDEPIKELEHALQSRGYQLIWPHNSADLLKFIEHNPRICGVIFDWD
EYDMELCSDINKLNEYLPLYAFINTHSTMDVSAHDMRMALWFFEYSLGVAEDIATRIQQY
TGEYLDNITPPFTRALFTYVKEGKYTFCTPGHMAGTAYQKSPVGCLFYDFFGGNTLKADV
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYMVTNGTSTSNKIVGMYAAPAGSTLLI
DRNCHKSLAHLLMMSDVVPLWLSPTRNALGILGGIPRREFSHAAIEHKVAAIPGASWPIH
AVITNSTYDGLLYNTNWIKQTLDVPSIHFDSAWVPYTNFHPIYAGKSGMSGERVPGKVFF
ETQSTHKMLAAFSQASLIHIKGEYDEETFNEAFMMHTTTSPSYPLVASIETAAAMLRGNP
GKRLINRSVERALHFRKEVQRLKDEADGWFFDIWQPEEIDEAECWPVSPGESWHGFRDAD
ADHMFLDPVKVTILTPGMDEQGTMSDEGIPAALVAKFLDERGVVVEKTGPYNLLFLFSIG
IDKTRAMGLLRGLMEFKRAYDLNLRVKNMLPDLYAEDPDFYRNMRIQDLAQGIHRLIRQH
DLPRLMLQAFDVLPEMKLTPHKAWQRQVKGEVETVELENLVGRVSANMILPYPPGVPLLM
PGEMITEESRAVLDFLLMLCSVGRHYPGFETDIHGAKRDEQGVYWVRVLK