Protein Info for MPMX20_00195 in Enterobacter sp. TBS_079

Annotation: Pantothenate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00554: pantothenate kinase
  • amino acids 2 to 308 (307 residues), 576.5 bits, E=7e-178
• PF00485: PRK
  • amino acids 82 to 237 (156 residues), 49.1 bits, E=3.1e-17

Best Hits

Swiss-Prot: 97% identical to COAA_ENT38: Pantothenate kinase (coaA) from Enterobacter sp. (strain 638)

KEGG orthology group: K00867, type I pantothenate kinase [EC: 2.7.1.33] (inferred from 98% identity to enc:ECL_00236)

MetaCyc: 91% identical to pantothenate kinase (Escherichia coli K-12 substr. MG1655)
Pantetheine kinase. [EC: 2.7.1.34]; Pantothenate kinase. [EC: 2.7.1.34, 2.7.1.33]

Predicted SEED Role

"Pantothenate kinase (EC 2.7.1.33)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.33)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• phosphopantothenate biosynthesis I (4/4 steps found)
• phosphopantothenate biosynthesis II (1/3 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.33 or 2.7.1.34

Protein Sequence (308 amino acids)

>MPMX20_00195 Pantothenate kinase (Enterobacter sp. TBS_079)
MTPYLQFNRSQWAALRDSVPMTLTEGEIARLKGINEDLSLEEVAEIYLPLSRLLNFYISS
NLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRSVELITTDG
FLHPNEVLKERGLMKKKGFPLSYDMHRLVKFVSDLKSGAPNVTAPVYSHLIYDRIPGGDK
TVVQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQNWYINRFLKFR
EGAFTDPDSYFHHYAQLSEEEAINVARGLWNEINYVNLKENILPTRERASLILTKSEKHA
VDQIRLRK