Protein Info for MPMX20_00134 in Enterobacter sp. TBS_079
Annotation: Mannitol-1-phosphate 5-dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 93% identical to MTLD_SALSV: Mannitol-1-phosphate 5-dehydrogenase (mtlD) from Salmonella schwarzengrund (strain CVM19633)
KEGG orthology group: K00009, mannitol-1-phosphate 5-dehydrogenase [EC: 1.1.1.17] (inferred from 97% identity to enc:ECL_00169)MetaCyc: 89% identical to mannitol-1-phosphate 5-dehydrogenase (Escherichia coli K-12 substr. MG1655)
Mannitol-1-phosphate 5-dehydrogenase. [EC: 1.1.1.17]
Predicted SEED Role
"Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)" in subsystem Mannitol Utilization (EC 1.1.1.17)
MetaCyc Pathways
- hexitol fermentation to lactate, formate, ethanol and acetate (18/19 steps found)
- superpathway of hexitol degradation (bacteria) (16/18 steps found)
- mannitol cycle (4/5 steps found)
- mannitol degradation I (1/1 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (382 amino acids)
>MPMX20_00134 Mannitol-1-phosphate 5-dehydrogenase (Enterobacter sp. TBS_079) MKALHFGAGNIGRGFIGKLLADAGITLTFADVNQVVLDALNARHSYQVHVVGENEQVETV SGVNAVSSIGEDVIDLIASVDLVTTAVGPVVLERIAPAVAKGLAKRKAQGIDTPLNIIAC ENMVRGTTQLKGHVLAAVADEDKAWVEAHVGFVDSAVDRIVPPSESATHDPLEVTVETFS EWIVDKTQFKGVLPTIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL DESIRAVVKGAMEESGAVLIKRYGFDAEKHAAYIQKILGRFENPYLKDDVERVGRQPLRK LSAGDRLIKPLLGTLEYGLAHANLVKGIAAAMHYRSEQDPQAQELAQLINDKGPQGALAQ ISGLDANSDVVVEAVNAYNAIK