Protein Info for MPMX20_00096 in Enterobacter sp. TBS_079

Annotation: Coenzyme A biosynthesis bifunctional protein CoaBC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00521: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
  • amino acids 4 to 395 (392 residues), 537.8 bits, E=8.2e-166
• PF02441: Flavoprotein
  • amino acids 7 to 176 (170 residues), 114 bits, E=5.6e-37
• PF04127: DFP
  • amino acids 188 to 369 (182 residues), 248.5 bits, E=4.3e-78

Best Hits

Swiss-Prot: 90% identical to COABC_ECOL6: Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 97% identity to enc:ECL_00122)

MetaCyc: 90% identical to fused 4'-phosphopantothenoylcysteine decarboxylase and phosphopantothenoylcysteine synthetase (Escherichia coli K-12 substr. MG1655)
Phosphopantothenate--cysteine ligase. [EC: 6.3.2.5]; Phosphopantothenoylcysteine decarboxylase. [EC: 6.3.2.5, 4.1.1.36]

Predicted SEED Role

"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• coenzyme A biosynthesis I (bacteria) (4/4 steps found)
• coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
• coenzyme A biosynthesis III (archaea) (3/4 steps found)
• taurine biosynthesis II (1/4 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.36 or 6.3.2.5

Protein Sequence (404 amino acids)

>MPMX20_00096 Coenzyme A biosynthesis bifunctional protein CoaBC (Enterobacter sp. TBS_079)
MMSLAGKKIVLGVSGGIAAYKAPELVRRLRERGADVRVAITEGGKAFITPLSLQAVSGYP
VSDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVAAGMANDLVSTICLATPAPVA
VVPAMNQQMYRNAATQHNLTTLASRGLLIWGPDSGSQACGDVGPGRMLDPLTIVELAAGH
FSPVNDLQHLNIMITAGPTREPLDPVRYITNHSSGKMGFAIAAAAAKRGAKVTLVSGPVS
LPTPPFVQRIDVTTALEMDAAVQAHAQNQQIFIGCAAVADYRAETISGSKIKKQGDELTL
KMVKNPDIVAGVAALKSHRPYVVGFAAETNNVEEYARQKRTRKNLDLICANDVSLATQGF
NSDSNALHLFWQDGDKVLPLERKELLGQQLLDEIVTRYDEKNRR