Protein Info for MMP_RS08185 in Methanococcus maripaludis S2

Annotation: tryptophan--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 358 PF00579: tRNA-synt_1b" amino acids 60 to 339 (280 residues), 193.5 bits, see alignment E=2.7e-61 TIGR00233: tryptophan--tRNA ligase" amino acids 61 to 353 (293 residues), 339.3 bits, see alignment E=1.2e-105

Best Hits

Swiss-Prot: 72% identical to SYW_METJA: Tryptophan--tRNA ligase (trpS) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K01867, tryptophanyl-tRNA synthetase [EC: 6.1.1.2] (inferred from 100% identity to mmp:MMP1592)

Predicted SEED Role

"Tryptophanyl-tRNA synthetase (EC 6.1.1.2)" (EC 6.1.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LWW2 at UniProt or InterPro

Protein Sequence (358 amino acids)

>MMP_RS08185 tryptophan--tRNA ligase (Methanococcus maripaludis S2)
LITPWDVSDDLDYKKTMEQFGVNPISEIVKTLKEPHNFMKRGIVFGHRDFQKIADAMNNG
KDFTVVSGMMPSGKMHFGHKMVVDQLLYYQKYGADIYIPIADLEAYWARGMDFETTKKLA
IEEYITNYIALGLDPEKIHVYLQSKNETVKDLAMRLSKRVNFTEMKGIYGFSGETNIGHV
FAPVVQVADILHPQLEKKVPVVVPVGIDQDPHIRLTRDIAGRYKDFKFIAPSSTYHRFIT
GLLGGKMSSSKPETAIYLSDEPTKSFKKKVMSCKTGGRETLEEQKKLGGVPEECVVYELY
TYHLIEDDKELKKLYDQCKSGELTCGTCKKECYQKLVEFMTDLQEKREQAKEVAAKLL