Protein Info for MMP_RS08160 in Methanococcus maripaludis S2

Annotation: EamA family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 137 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 31 to 50 (20 residues), see Phobius details amino acids 62 to 83 (22 residues), see Phobius details amino acids 90 to 110 (21 residues), see Phobius details amino acids 117 to 135 (19 residues), see Phobius details PF00892: EamA" amino acids 2 to 134 (133 residues), 74.4 bits, see alignment E=5e-25

Best Hits

Swiss-Prot: 58% identical to YD3A_METJA: Uncharacterized protein MJ1333.1 (MJ1333.1) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K08978, putative membrane protein (inferred from 100% identity to mmp:MMP1587)

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LWW7 at UniProt or InterPro

Protein Sequence (137 amino acids)

>MMP_RS08160 EamA family transporter (Methanococcus maripaludis S2)
MEGVILGLLAAVLYGIGTFFAKVVSNEDPYLQWIIVNIVGIVLCVILFGGKCRNLLDYPN
KVLIYGVIAAILVICGTLALYYGLNKGKASVVVPLSSIGPAITTVLAIIFLKEQLSFTQI
AGIAMILSGVIVLSINS