Protein Info for MMP_RS08065 in Methanococcus maripaludis S2

Annotation: tetrahydromethanopterin S-methyltransferase subunit H

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01114: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H
  • amino acids 1 to 318 (318 residues), 518.3 bits, E=3.2e-160
• PF02007: MtrH
  • amino acids 6 to 308 (303 residues), 479 bits, E=2.7e-148

Best Hits

Swiss-Prot: 100% identical to MTRH_METMP: Tetrahydromethanopterin S-methyltransferase subunit H (mtrH) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00584, tetrahydromethanopterin S-methyltransferase subunit H [EC: 2.1.1.86] (inferred from 100% identity to mmp:MMP1567)

Predicted SEED Role

"N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H (EC 2.1.1.86)" in subsystem Methanogenesis (EC 2.1.1.86)

MetaCyc Pathways

• methanogenesis from H₂ and CO₂ (6/6 steps found)
• methyl-coenzyme M oxidation to CO₂ II (6/6 steps found)
• methyl-coenzyme M oxidation to CO₂ I (5/6 steps found)
• methanogenesis from acetate (4/6 steps found)
• methanogenesis from methoxylated aromatic compounds (1/3 steps found)
• superpathway of methanogenesis (11/21 steps found)

KEGG Metabolic Maps

• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.86

Use Curated BLAST to search for 2.1.1.86

Sequence Analysis Tools

See Q6LWY7 at UniProt or InterPro

Protein Sequence (319 amino acids)

>MMP_RS08065 tetrahydromethanopterin S-methyltransferase subunit H (Methanococcus maripaludis S2)
MFRFDKEQMVIEFAGAKFGGQPGEYPTALSGTIFYSRHKIVEDAKKGIFDKKAAEALINK
QAEMQDITGNSAFVQVFGGTEEALVNYIDFVSEVWDGPMLLDSTSGKARMAAANRATEAG
YANQCIYNSINVAAEDEEIENLTNSDVEASIVLCFDPMDPSVAGKLNVLNDGGKTKDIGM
LELAEKAGIKYPLIDVAVTPMGNGAGHAVRAAFAVKAKLGLPVGSGIHNVPSAWDWLREF
RKGLREEGKDQIAKDVHHVCDIGANIVQTMTSGDYVLYGPIDNAELAFPAVAMTDMIIAE
TAKEMGTVPVAEHPLNKLI