Protein Info for MMP_RS07655 in Methanococcus maripaludis S2
Annotation: bifunctional NADP phosphatase/NAD kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to NPPNK_METMP: Bifunctional NADP phosphatase/NAD kinase (MMP1489) from Methanococcus maripaludis (strain S2 / LL)
KEGG orthology group: K00858, NAD+ kinase [EC: 2.7.1.23] (inferred from 100% identity to mmp:MMP1489)Predicted SEED Role
"NAD kinase (EC 2.7.1.23)" in subsystem NAD and NADP cofactor biosynthesis global (EC 2.7.1.23)
MetaCyc Pathways
- NADP biosynthesis (1/1 steps found)
- NAD phosphorylation and transhydrogenation (1/2 steps found)
- NAD phosphorylation and dephosphorylation (1/3 steps found)
- cytosolic NADPH production (yeast) (1/5 steps found)
- mitochondrial NADPH production (yeast) (1/5 steps found)
- NAD(P)/NADPH interconversion (1/6 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (1/8 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.1.23
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LX63 at UniProt or InterPro
Protein Sequence (566 amino acids)
>MMP_RS07655 bifunctional NADP phosphatase/NAD kinase (Methanococcus maripaludis S2) MDMLEMALNIAKDIEKSVKPLIGWEKSNEVVKIGADGTPTKRIDLIAENVAINSIEKVCS AILISEEIGFKRIGKNKPEYVIVLDPVDGTYNSLKDIPFYSAAVAIGRIDKFADNLEELI NNLKMKDLEVGVVRNIATGDTYYAEKGKGAHFLRKGEKKSISISNSSNLKDSSIGLFAHD ISIDTLKFIKDRRFRRIRLFGSIALEMCYVAKGALDAFINVNETTRLCDIAAGYVIIKEA GGIVTDKNGQEVNLDLDVNSKVSVICSNEMLHKKLVGIFGNRWRIKPTNFGIISRIDNEE SIEVADNVIKYLDSKGIKYELDSSTYNALKNRLTKKCDIISNIEEISHMISIGGDGTVLR ASKMIEGNEIPMVCINMGTVGFLTEFNKDEIFSAIDSIICGSYKVEKRTKLMGFAKLSDG KQHILNDSLNEVVITTKNPAKMMHFEVYIDGSLVEDVRADGIIVSTPNGSTAYSLSSGGP IIEPTVEGFVIVPICPFKLSSRPLVVNANSEIKIKLLKKSTYVVIDGNTEFEAKKGDEII LRKSESNAYFVKGDNFYNKLKKLSLM