Protein Info for MMP_RS07450 in Methanococcus maripaludis S2

Annotation: energy-converting NiFe hydrogenase A subunit EhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 88 signal peptide" amino acids 5 to 6 (2 residues), see Phobius details transmembrane" amino acids 7 to 23 (17 residues), see Phobius details amino acids 42 to 71 (30 residues), see Phobius details PF17367: NiFe_hyd_3_EhaA" amino acids 2 to 81 (80 residues), 49.5 bits, see alignment E=2.1e-17

Best Hits

Swiss-Prot: 100% identical to EHAA_METMP: Probable [NiFe]-hydrogenase-type-3 Eha complex membrane subunit A (ehaA) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K14092, energy-converting hydrogenase A subunit A (inferred from 100% identity to mmp:MMP1448)

Predicted SEED Role

"Energy conserving hydrogenase Eha transmembrane protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXA4 at UniProt or InterPro

Protein Sequence (88 amino acids)

>MMP_RS07450 energy-converting NiFe hydrogenase A subunit EhaA (Methanococcus maripaludis S2)
MVLLINYAVSLVSAIVVGAVLGMKLSFDMDSFEGSVLFPTPFVAIGLTALIGYLITLDLV
SSIIIGIFASVFSKFTNKIFPGVNNDIN