Protein Info for MMP_RS07175 in Methanococcus maripaludis S2

Annotation: type I 3-dehydroquinate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01093: 3-dehydroquinate dehydratase, type I
  • amino acids 1 to 214 (214 residues), 218.4 bits, E=7e-69
• PF01487: DHquinase_I
  • amino acids 3 to 214 (212 residues), 205.1 bits, E=8.9e-65

Best Hits

Swiss-Prot: 100% identical to AROD_METMP: 3-dehydroquinate dehydratase (aroD) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K03785, 3-dehydroquinate dehydratase I [EC: 4.2.1.10] (inferred from 100% identity to mmp:MMP1394)

MetaCyc: 100% identical to 3-dehydroquinate dehydratase (Methanococcus maripaludis)
3-dehydroquinate dehydratase. [EC: 4.2.1.10]

Predicted SEED Role

"3-dehydroquinate dehydratase I (EC 4.2.1.10)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Quinate degradation (EC 4.2.1.10)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (17/18 steps found)
• chorismate biosynthesis II (archaea) (12/12 steps found)
• superpathway of L-tryptophan biosynthesis (12/13 steps found)
• superpathway of L-phenylalanine biosynthesis (9/10 steps found)
• superpathway of L-tyrosine biosynthesis (9/10 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis I (6/7 steps found)
• gallate biosynthesis (2/3 steps found)
• quinate degradation I (1/3 steps found)
• quinate degradation II (1/3 steps found)
• superpathway of chorismate metabolism (25/59 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (2/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (3/42 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.10

Sequence Analysis Tools

See Q6LXF7 at UniProt or InterPro

Protein Sequence (218 amino acids)

>MMP_RS07175 type I 3-dehydroquinate dehydratase (Methanococcus maripaludis S2)
MICIPVIDKDVSDAINSAKEALKYGDIVEFRIDLLNDVNFKDIEEFSKIPSIITIRAEWE
GGAWRKSNEERIELLKNAIKNNAKFIDIELKEEKNLELVKYRNEIGSTTKIIVSYHDFEK
TPEIDELIDVVEKELKIGDIAKFATFAHSKEDTLKILNLMNRYSGKIIAIGMGESGKLTR
ILGLDFGSILTFASMGGKASAPGQVDVKKLKEILKLIN