Protein Info for MMP_RS06530 in Methanococcus maripaludis S2

Annotation: bifunctional hexulose-6-phosphate synthase/ribonuclease regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00215: OMPdecase
  • amino acids 8 to 211 (204 residues), 115.3 bits, E=3.9e-37
• PF03737: RraA-like
  • amino acids 243 to 392 (150 residues), 160.1 bits, E=4.9e-51

Best Hits

KEGG orthology group: K13831, 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC: 4.1.2.43 5.3.1.27] (inferred from 100% identity to mmp:MMP1270)

Predicted SEED Role

"D-arabino-3-hexulose 6-phosphate formaldehyde lyase / Hypothetical protein with distant similarity to Ribonuclease E inhibitor RraA (former MenG)" in subsystem Formaldehyde assimilation: Ribulose monophosphate pathway

MetaCyc Pathways

• formaldehyde assimilation II (assimilatory RuMP Cycle) (8/9 steps found)
• pentose phosphate pathway (oxidative branch) II (2/2 steps found)
• formaldehyde oxidation I (3/6 steps found)

KEGG Metabolic Maps

• Methane metabolism
• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.43 or 5.3.1.27

Sequence Analysis Tools

See Q6LXS8 at UniProt or InterPro

Protein Sequence (438 amino acids)

>MMP_RS06530 bifunctional hexulose-6-phosphate synthase/ribonuclease regulator (Methanococcus maripaludis S2)
MQFKSELPPVQVALDLVDLPRAINIAKEAVLGGATWVEAGTPLIKSEGMNAIRELRKNFP
TLTIVADMKTMDAGSTEVEMAAKAGANVILILGVGPDSMIKDAVKAGKKYGVLVGTDLIA
TEDPVKRAVELEEMGVDIINIHVGLDQQVLNVDPVELVKRVSENCKKAKIAAAGGLNSET
AVKAYEAGADIIIAGGTLYKSADPEQTARDIVKSLETGKPVKTDKFKKFNEDELGSAFDI
VSTSNISDAMHRTGEMKGLKPVWNSERPLKFAGPAVTVRTYSGDWSKPVSAIDNCEAGNV
LVIDNCSSEIACWGGLATLSCKTKGVVAVVIDGAVRDVEEILKIGIPVYARSITPTAGEP
KGFGEINAVIECAGRTVEPGDWIVGDENGIIVVPKNEAMEIANRAIDVKEREDRVKEEIT
RGTTLAKTIRLKDWELKK