Protein Info for MMP_RS06480 in Methanococcus maripaludis S2

Annotation: ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 382 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF13379: NMT1_2" amino acids 30 to 300 (271 residues), 96.6 bits, see alignment E=2.2e-31

Best Hits

KEGG orthology group: K02051, sulfonate/nitrate/taurine transport system substrate-binding protein (inferred from 100% identity to mmp:MMP1260)

Predicted SEED Role

"ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components" in subsystem Alkanesulfonate assimilation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXT7 at UniProt or InterPro

Protein Sequence (382 amino acids)

>MMP_RS06480 ABC transporter substrate-binding protein (Methanococcus maripaludis S2)
VLIIKKFVIIASLLLALLFAGCTDSTTSDGEVADLKVAYLPSDHDAPLFVAAEYPNVFKD
EYGVYLQEVENKKTYELYENDKLVANVEFIKVIEGGAKIMTLMAQGQVDVGLNGVPPAVF
SIDQGTNAKIVSPAQSEGSAIVIRSDIPAETWDEFVVYIKEQADSGVQLKIGHPLPTSIQ
YVMIKSALDTEGITYTENPNDKDAMVQLINCKGQGTMPQLLSSNELDAVIAWEPTPEQLA
VLGIGKSVIYSGDIPPAGMWVNHPCCVFVASNDAVENKRESVKAFLKLMALANNEITANP
KLAVNASAEWLGTDLEVEELSIPNIGFTNEIGSLEAIGPEFVKVMDEQGAMTGQLAGLED
AEEINAILYDFTLYNEIMEEIQ