Protein Info for MMP_RS06260 in Methanococcus maripaludis S2

Annotation: histidinol-phosphate transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to HIS8_METMP: Histidinol-phosphate aminotransferase (hisC) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K00817, histidinol-phosphate aminotransferase [EC: 2.6.1.9] (inferred from 100% identity to mmp:MMP1216)

MetaCyc: 34% identical to histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous) (Bacillus subtilis subtilis 168)
Histidinol-phosphate transaminase. [EC: 2.6.1.9]; Aspartate transaminase. [EC: 2.6.1.9, 2.6.1.1, 2.6.1.27, 2.6.1.5, 2.6.1.57]; 2.6.1.1,2.6.1.57,2.6.1.27 [EC: 2.6.1.9, 2.6.1.1, 2.6.1.27, 2.6.1.5, 2.6.1.57]

Predicted SEED Role

"Aspartate aminotransferase (EC 2.6.1.1) @ Histidinol-phosphate aminotransferase (EC 2.6.1.9)" (EC 2.6.1.1, EC 2.6.1.9)

MetaCyc Pathways

superpathway of aromatic amino acid biosynthesis (17/18 steps found)
superpathway of L-isoleucine biosynthesis I (12/13 steps found)
superpathway of histidine, purine, and pyrimidine biosynthesis (35/46 steps found)
L-histidine biosynthesis (9/10 steps found)
superpathway of L-phenylalanine biosynthesis (9/10 steps found)
superpathway of L-tyrosine biosynthesis (9/10 steps found)
superpathway of L-threonine biosynthesis (6/6 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
L-phenylalanine biosynthesis I (3/3 steps found)
L-tyrosine biosynthesis I (3/3 steps found)
L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
malate/L-aspartate shuttle pathway (2/2 steps found)
3-(4-hydroxyphenyl)pyruvate biosynthesis (1/1 steps found)
L-aspartate biosynthesis (1/1 steps found)
L-aspartate degradation I (1/1 steps found)
aspartate superpathway (18/25 steps found)
(R)-cysteate degradation (2/3 steps found)
L-asparagine degradation III (mammalian) (2/3 steps found)
TCA cycle VIII (Chlamydia) (4/6 steps found)
L-glutamate degradation II (1/2 steps found)
L-tryptophan degradation IV (via indole-3-lactate) (1/2 steps found)
L-tyrosine degradation II (1/2 steps found)
atromentin biosynthesis (1/2 steps found)
superpathway of L-methionine biosynthesis (transsulfuration) (6/9 steps found)
L-phenylalanine degradation III (2/4 steps found)
L-tyrosine degradation III (2/4 steps found)
superpathway of L-aspartate and L-asparagine biosynthesis (2/4 steps found)
anaerobic energy metabolism (invertebrates, cytosol) (4/7 steps found)
L-phenylalanine degradation II (anaerobic) (1/3 steps found)
L-tyrosine degradation IV (to 4-methylphenol) (1/3 steps found)
indole-3-acetate biosynthesis VI (bacteria) (1/3 steps found)
sulfolactate degradation III (1/3 steps found)
superpathway of L-methionine biosynthesis (by sulfhydrylation) (7/12 steps found)
L-tryptophan degradation VIII (to tryptophol) (1/4 steps found)
coenzyme M biosynthesis II (2/6 steps found)
superpathway of sulfolactate degradation (2/6 steps found)
4-hydroxybenzoate biosynthesis I (eukaryotes) (1/5 steps found)
L-phenylalanine degradation VI (reductive Stickland reaction) (1/5 steps found)
L-tryptophan degradation XIII (reductive Stickland reaction) (1/5 steps found)
L-tyrosine degradation I (1/5 steps found)
L-tyrosine degradation V (reductive Stickland reaction) (1/5 steps found)
superpathway of plastoquinol biosynthesis (1/5 steps found)
C4 photosynthetic carbon assimilation cycle, NAD-ME type (4/11 steps found)
L-phenylalanine degradation IV (mammalian, via side chain) (2/9 steps found)
Methanobacterium thermoautotrophicum biosynthetic metabolism (35/56 steps found)
(S)-reticuline biosynthesis I (2/11 steps found)
rosmarinic acid biosynthesis I (1/10 steps found)
superpathway of anaerobic energy metabolism (invertebrates) (6/17 steps found)
indole-3-acetate biosynthesis II (2/12 steps found)
tropane alkaloids biosynthesis (1/11 steps found)
C4 photosynthetic carbon assimilation cycle, PEPCK type (3/14 steps found)
superpathway of rosmarinic acid biosynthesis (1/14 steps found)
superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (2/16 steps found)
superpathway of chorismate metabolism (25/59 steps found)
anaerobic aromatic compound degradation (Thauera aromatica) (2/27 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.1, 2.6.1.57

Use Curated BLAST to search for 2.6.1.1 or 2.6.1.27 or 2.6.1.5 or 2.6.1.57 or 2.6.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P61003 at UniProt or InterPro

Protein Sequence (371 amino acids)

>MMP_RS06260 histidinol-phosphate transaminase (Methanococcus maripaludis S2)
MSIDDKVRSIVKEFKAYVPGKSKEEIARNYGIDPERIIKLGSNENPWGCSPKIEEKLLNE
VSNLHQYPQPINPELMDEISKFTKMPVENIIVGGDGADEVIDNIMRILIDEGDEVIIPIP
TFTQYAISAKIHGANIKWAKFDEENGFKLDVESVLNNITEKTKAIFLCTPNNPTGNVIPT
EDIKKIVESTDALVMIDHAYIEYSKEEYDLTSWALKYDNVLVLRTFSKVFGLAGQRVGYG
VTSKKVVDYMMRIKPIFSLTRASQVSAITALQDKEFFEKCLKEGIESREEIYNGLKKFKQ
LEVYPTEANYMLVKVKNGMNSSEFCEALLKKGVIVRDCYSFEGLEPYYFRVSIGTSEENE
RFLKIMSEIVE