Protein Info for MMP_RS06255 in Methanococcus maripaludis S2

Annotation: cobyric acid synthase CobQ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 492 PF13500: AAA_26" amino acids 5 to 231 (227 residues), 69.4 bits, see alignment E=5.9e-23 PF01656: CbiA" amino acids 5 to 231 (227 residues), 83 bits, see alignment E=2.7e-27 TIGR00313: cobyric acid synthase CobQ" amino acids 5 to 489 (485 residues), 653.8 bits, see alignment E=8e-201 PF07685: GATase_3" amino acids 255 to 443 (189 residues), 150.6 bits, see alignment E=6.5e-48

Best Hits

Swiss-Prot: 100% identical to COBQ_METMP: Probable cobyric acid synthase (cobQ) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to mmp:MMP1215)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXX9 at UniProt or InterPro

Protein Sequence (492 amino acids)

>MMP_RS06255 cobyric acid synthase CobQ (Methanococcus maripaludis S2)
MAKFIMVVGTSSNSGKTVLVSGICRMLSNKGYKVAPFKSQNMSLNSRVSVEDGEIAVAQY
TQAMAARAEPSVHFNPILLKPKGNFVSQVIVHGNPYEDKDYNEYRSKKDDFLVKIKESID
YLDKNYDYVVIEGAGSCCEINLLNDDIANLKVAEIAGADAILVSDIDRGGVFASIYGTVQ
LLPENWKKLLKGFVINKFRGNIDVLKDGFEKIEELTNIPVIGTIPYDETLVLPEEDSQAL
DGKRVFGNLKSPIEVNVVKFSKIANFTDVDPFSSDCLMKYIDFNENITGDILILPGTRCS
TVEMDLMKKYGMDKKILEFVENGGIVLGICGGYQALGKMLFDEDFSEGDVGTISGLGLFD
METTFGNKKAIKNSTGKISIFNQNFDVSGYELHEGYSVSNETPLISLSKGFGNCGDSYDG
SFKMIGDSYIFGTYFHGILENFEFRNYLVNLARSKKNLSKIEDDTYAELFNENMDKLSKI
IEENLDFSKIIG