Protein Info for MMP_RS06115 in Methanococcus maripaludis S2

Annotation: class II aldolase/adducin family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00596: Aldolase_II
  • amino acids 5 to 173 (169 residues), 175.4 bits, E=5.9e-56

Best Hits

Swiss-Prot: 100% identical to FUCA_METMP: L-fuculose phosphate aldolase (fucA) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01628, L-fuculose-phosphate aldolase [EC: 4.1.2.17] (inferred from 100% identity to mmp:MMP1187)

MetaCyc: 60% identical to fuculose-1-phosphate aldolase subunit (Methanocaldococcus jannaschii)
L-fuculose-phosphate aldolase. [EC: 4.1.2.17]

Predicted SEED Role

"Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases"

MetaCyc Pathways

• lactate biosynthesis (archaea) (4/5 steps found)
• L-fucose degradation I (2/4 steps found)
• D-arabinose degradation II (1/4 steps found)
• nucleoside and nucleotide degradation (halobacteria) (2/6 steps found)
• superpathway of fucose and rhamnose degradation (4/12 steps found)
• superpathway of pentose and pentitol degradation (3/42 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.17

Sequence Analysis Tools

See Q6LY06 at UniProt or InterPro

Protein Sequence (180 amino acids)

>MMP_RS06115 class II aldolase/adducin family protein (Methanococcus maripaludis S2)
MDLTEFIKICRLLYDRKYVVGSGGNVSIRDGNLIYITPTGLSLGFLTKEDICIADLNGNI
IKGKPTSELNMHLKIYQNKDSINAVVHTHSMYCTAFSALDKKLKLVTPEAEMVVKKIAYV
DYFPCGSLELAENVSECIEDSIILKNHGIVTLGKDITEAYIKTEVLEEVAQLNYIMNNLK