Protein Info for MMP_RS05800 in Methanococcus maripaludis S2

Annotation: B12-binding domain-containing radical SAM protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 438 PF19864: Radical_SAM_N2" amino acids 31 to 113 (83 residues), 52.2 bits, see alignment E=4.9e-18 PF04055: Radical_SAM" amino acids 172 to 328 (157 residues), 76.4 bits, see alignment E=3.2e-25

Best Hits

Swiss-Prot: 60% identical to Y966_METJA: Uncharacterized protein MJ0966 (MJ0966) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1123)

Predicted SEED Role

"Uncharacterized protein MJ0966"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY68 at UniProt or InterPro

Protein Sequence (438 amino acids)

>MMP_RS05800 B12-binding domain-containing radical SAM protein (Methanococcus maripaludis S2)
MAIKNVSIVYPNRFGGGIACLAVHVLTSHLNKYRDISANAYFIENYSKIKNSDAILITLQ
YENDYFNVVKIVKELKAQNPNAIFIAGGPCAISNPLPIQEFFDVFVVGEIEGTDTMYQLI
NGNFEIPGVYVPKTYNNEKIKRIYPKKLGIDDYPISQVTHESGAYGKAYLLEIGRGCIRN
CKFCMAKCIYAPPRYRKIEDLKHLVDEGLKNTDADKVSLIAPSVSDYRYVLDLCAHISEK
NVSISPSSLRADTITDELLEYLNLKTLTIAPEAGSEVLRKKIDKGITEENILNAVDIAKT
HGISTVKLYYMVGFPDETEEDIEEIINLTKKIKDNVRKVDVSINPMVPKPHTPFEDFEFD
MDSKTKIKYIEKSLRKIKVSVDFEKFNSMVAQTVLARGGSELSKVLNESRNTIELIKNVD
LDNYINKIEEKPWDFIEI