Protein Info for MMP_RS05680 in Methanococcus maripaludis S2

Annotation: phosphate signaling complex protein PhoU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 233 TIGR02135: phosphate transport system regulatory protein PhoU" amino acids 5 to 214 (210 residues), 186.1 bits, see alignment E=3.1e-59 PF01895: PhoU" amino acids 17 to 104 (88 residues), 86 bits, see alignment E=9.2e-29 amino acids 123 to 206 (84 residues), 51.6 bits, see alignment E=5e-18

Best Hits

Swiss-Prot: 49% identical to PHOU_METJA: Phosphate-specific transport system accessory protein PhoU homolog (MJ1009) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K02039, phosphate transport system protein (inferred from 100% identity to mmp:MMP1099)

Predicted SEED Role

"Phosphate transport system regulatory protein PhoU" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY92 at UniProt or InterPro

Protein Sequence (233 amino acids)

>MMP_RS05680 phosphate signaling complex protein PhoU (Methanococcus maripaludis S2)
MVRNAFSDQMKEIEDMINKMSEMCVKSLKNSITAFITNDIELAKVVRDWDDEIDLMEMEI
EEKCISFMARQQPVASDLREIITMIKIISKLEKVGDMASRIAKITINSEQNILRSKNGSI
LTIMDEILENMLKNSILSFGNRDLELAKKTYREDSKIDELYKVLCRDMTLKMIENPKIIS
EATDFLVVGTYLERVGNLCGSIGDRVAFMITGERLKEEEFDKLLNKATKKLEN