Protein Info for MMP_RS05645 in Methanococcus maripaludis S2

Annotation: AEC family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 304 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 33 to 53 (21 residues), see Phobius details amino acids 64 to 84 (21 residues), see Phobius details amino acids 96 to 119 (24 residues), see Phobius details amino acids 125 to 147 (23 residues), see Phobius details amino acids 161 to 183 (23 residues), see Phobius details amino acids 195 to 212 (18 residues), see Phobius details amino acids 220 to 242 (23 residues), see Phobius details amino acids 255 to 274 (20 residues), see Phobius details amino acids 281 to 301 (21 residues), see Phobius details PF03547: Mem_trans" amino acids 3 to 145 (143 residues), 81.4 bits, see alignment E=2.5e-27 amino acids 154 to 301 (148 residues), 74.9 bits, see alignment E=2.3e-25

Best Hits

Swiss-Prot: 53% identical to Y1031_METJA: Uncharacterized transporter MJ1031 (MJ1031) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07088, (no description) (inferred from 100% identity to mmp:MMP1092)

Predicted SEED Role

"Malate permease" in subsystem Pyruvate metabolism I: anaplerotic reactions, PEP

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY99 at UniProt or InterPro

Protein Sequence (304 amino acids)

>MMP_RS05645 AEC family transporter (Methanococcus maripaludis S2)
MIIMEIMYVIVFLILIGYISRHFKILDEKDRMVLNKIVIYIAMPATIFLQLLTNVAPSDL
PEFMKLPIIIFISTAACALLAYIAGKRLKLDNKSLGGFVLVASIGNTGFLGYPVILGFYG
EQGLLRAIFCDMSAIFCSMLLGTYIGVKLSGAKKSILKEVFTFPPLFTGIFTLILVLLHV
NLSIFPEFFTKSLEYMSSATIPLIMLSLGLSLSPKAAKFGIFYGILASIFRMVISPLVAF
PISESILSNQLDKQVTIMQSAMPSAMMPLVYAVIYDLDVKLVASACFVSTVVSLFALPIL
YTLM