Protein Info for MMP_RS05565 in Methanococcus maripaludis S2

Annotation: NTP transferase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03992: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase
  • amino acids 1 to 388 (388 residues), 521.6 bits, E=6.2e-161
• PF00483: NTP_transferase
  • amino acids 3 to 224 (222 residues), 155 bits, E=4e-49
• PF12804: NTP_transf_3
  • amino acids 3 to 112 (110 residues), 46.8 bits, E=5.9e-16
• PF00132: Hexapep
  • amino acids 355 to 389 (35 residues), 31.6 bits, 1.4e-11

Best Hits

Swiss-Prot: 100% identical to GLMU_METMP: Bifunctional protein GlmU (MMP1076) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K04042, bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC: 2.3.1.157 2.7.7.23] (inferred from 100% identity to mmp:MMP1076)

Predicted SEED Role

"N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)" in subsystem Peptidoglycan Biosynthesis or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.3.1.157, EC 2.7.7.23)

MetaCyc Pathways

• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (3/6 steps found)
• O-antigen building blocks biosynthesis (E. coli) (6/11 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (3/7 steps found)
• chitin biosynthesis (4/9 steps found)
• peptidoglycan recycling I (3/14 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (9/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.157 or 2.7.7.23

Sequence Analysis Tools

See Q6LYB5 at UniProt or InterPro

Protein Sequence (411 amino acids)

>MMP_RS05565 NTP transferase domain-containing protein (Methanococcus maripaludis S2)
MDAIILCAGKGTRLHPITESRPKPMIPIAGKPIIEHIIEKIENHVEKIYLIVGYQKEKII
DYFKDNPKIEYILQEKQLGTGHAVLTAKNFIKGDFLVLNGDVIFEDSIDEILNYENAVSL
SNVDNPENFGVIELGYDNKIINLLEKPKKEEITSNLINAGIYKLQNSVFGILENLAPSER
GEIELTDALKKLIENGKLHGVELKGYWNDIGHPWDVLSANNHFLNKIISKVSGKIENTVS
ITGNVIIEEGAVIKPNSVIEGPAIIKSGSIVGPLAYVRPNTVLMKNTFVGNSSEIKGSII
FENTKIPHLSYVGDSIIGANCNFGCNTITANLRFDDKPVIVNIKGKPVKSVRKLGAIIGD
CVKTGIQVSFMPGVKIGSNSLIGANCLIDRDIEQESFVYKKDELVITKKRN