Protein Info for MMP_RS05530 in Methanococcus maripaludis S2

Annotation: signal peptide peptidase SppA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 308 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details TIGR00706: signal peptide peptidase SppA, 36K type" amino acids 35 to 252 (218 residues), 216.3 bits, see alignment E=1.8e-68 PF01343: Peptidase_S49" amino acids 105 to 253 (149 residues), 167 bits, see alignment E=1.5e-53

Best Hits

KEGG orthology group: K04773, protease IV [EC: 3.4.21.-] (inferred from 100% identity to mmp:MMP1069)

Predicted SEED Role

"Protease IV (EC 3.4.21.-)" (EC 3.4.21.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYC2 at UniProt or InterPro

Protein Sequence (308 amino acids)

>MMP_RS05530 signal peptide peptidase SppA (Methanococcus maripaludis S2)
LKKIYYYSIAVFLIIAILMVGLLVFVSSDGISSKNIALINIDGTITLESSDSGLFSSIQP
GVNDYVEWLDDAENNDNIKAVIIKINSPGGGAVASEKLSRKIKEVSEKKPVVAYIENMGA
SAAYQAASSTNYIVAERQAVVGSIGVRMELIHYYGLMEKLGINTTSITGGKYKDIGTPTR
SMTEEEYAMLESMVNESYYEFVSWVAENRNMTINETLEVADGKIYSGTQAQRVGLVDITG
TEDDAVDMAVKLGNITNPDIYEYGKTSSANLFGMTFNDCLYSFGYGLGMGISENLNTEES
FKSYQVYY