Protein Info for MMP_RS05515 in Methanococcus maripaludis S2

Annotation: cyclic pyranopterin monophosphate synthase MoaC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00581: molybdenum cofactor biosynthesis protein C
  • amino acids 2 to 143 (142 residues), 174 bits, E=8.6e-56
• PF01967: MoaC
  • amino acids 12 to 150 (139 residues), 166 bits, E=2.3e-53

Best Hits

Swiss-Prot: 68% identical to MOAC_METJA: Probable cyclic pyranopterin monophosphate synthase (moaC) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K03637, molybdenum cofactor biosynthesis protein C (inferred from 99% identity to mmp:MMP1066)

MetaCyc: 40% identical to MoaC monomer (Thermus thermophilus HB8)
RXN-17809 [EC: 4.6.1.17]

Predicted SEED Role

"Molybdenum cofactor biosynthesis protein MoaC" in subsystem Molybdenum cofactor biosynthesis

MetaCyc Pathways

• molybdopterin biosynthesis (1/6 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.6.1.17

Protein Sequence (153 amino acids)

>MMP_RS05515 cyclic pyranopterin monophosphate synthase MoaC (Methanococcus maripaludis S2)
VLTHVDENGVKMVDVSNKKDVERICTAVGFIKLKKSTIEKITKKELIKGDVLTTAQVAGV
MAVKNTSNIIPMCHPLPIESIKVNFEIFEDKIKAEARVKATYKTGIEMESLTGVSVALLT
IWDMVKAIEKDEFGQYPNTQIYGIEVTEKIKKE