Protein Info for MMP_RS05340 in Methanococcus maripaludis S2

Annotation: OB-fold nucleic acid binding domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 642 PF01336: tRNA_anti-codon" amino acids 74 to 148 (75 residues), 30.8 bits, see alignment E=4.4e-11 amino acids 203 to 263 (61 residues), 30.7 bits, see alignment 4.8e-11

Best Hits

Swiss-Prot: 44% identical to RPA_METJA: Replication factor A (rpa) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07466, replication factor A1 (inferred from 100% identity to mmp:MMP1032)

Predicted SEED Role

"Replication factor A (ssDNA-binding protein)" in subsystem DNA replication, archaeal

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LYF9 at UniProt or InterPro

Protein Sequence (642 amino acids)

>MMP_RS05340 OB-fold nucleic acid binding domain-containing protein (Methanococcus maripaludis S2)
MNIDKLKQKILSKISEKELEKKVNEKIEENSGLLGEESAVMLVAQELGIEITYGDDEEEY
DFSIKDIADGQKNVEVTGKIIEISPAKDFNRKDGSTGKLASVTIGDNTGITRLTLWNDKT
DLIEGLKKGDVVKIENAFSRKWNDKVELNSGSELSIEKLKKYDESRYPILKDNYKISELM
PNLSGTINAEVVTAYPKKEFSRKDGTKGQLKSLFLKDDTGSIRGTLWNELADFEVKKGDI
AEVSGYVKQGYSGLEISVDNIGIIEKSVKEEKPVEKLSISELTSFDGEYVTVSGNIVNIS
GSREVQFSDRTAEVQDIYINDGTGMVKTAFWGTNRSILDGLKEGDYVTISNAKLRTYTDN
TGEKRADLTYNYMSELKKDESASKKILEEITEIKDILNGSAENSDVTVVAMVTNAYPVNE
FQRSSGGTGKVRNIMLEDGTGSIRMALWDSDAETEISEGDVVKLIHGYAKESGEYMDLST
GRFGRIEVNPKGVSIKSPRNYIADLEEGVSTEISGTIVDYRKQDVILNLCPNCRKRLNLV
DNKYLCEVCGEVEPNELLVSNLTVDDGTGVINCRVYGSNVEKVTELSKNKLKEMNMDALA
DVLGKDVLFYGTPSFRNDDLDFAVKRVNFVDVSKELEVLKQH